Diol synthesis by dihydroxylation - Organic Chemistry Portal
WEBTBAI catalyzes an efficient, mild, and regioselective synthesis of 4-aryl/alkyl-1-peroxy-but-3-en-2-ols in good yields from 1-substituted-1,3-butadienes in the presence of hydroperoxides and water. This regioselective orthogonal dioxygenation of a diene can be executed in a simple operation and tolerates a wide range of substrates.
Biosynthesizing structurally diverse diols via a general route ...
WEBMar 24, 2022 · In this study, we design a diol biosynthetic platform based on a biosynthetic principle of combining an oxidation pathway and a reduction pathway for the respective formation of the two hydroxyl...
Diol - Wikipedia
WEBSynthesis of classes of diols. Geminal diols. Propane-2,2-diol, an example of a geminal diol. A geminal diol has two hydroxyl groups bonded to the same atom. These species arise by hydration of the carbonyl compounds.
Overcoming the low reactivity of biobased, secondary diols in
WEBNov 30, 2022 · Here we report a simple, yet innovative, synthesis strategy to overcome the inherently low reactivity of secondary diols in polyester synthesis. It enables the synthesis of fully biobased...
Diol synthesis by substitution - Organic Chemistry Portal
WEBA cooperative catalysis system of an in situ generated chiral palladium complex and a boron reagent enables an enantioselective construction of tertiary C-O bond via asymmetric allylic substitution of racemic vinylethylene carbonates with water and alcohols.
New pathways and metabolic engineering strategies for microbial ...
WEBDec 1, 2022 · This review describes the recent efforts in the development of novel synthetic pathways and metabolic engineering strategies for the biological production of C2∼C5 diols. We also discussed the main challenges and future perspectives for the microbial processes toward industrial application.
1,3-Diol synthesis by addition and hydration - Organic Chemistry …
WEBCu-catalyzed highly regio- and stereoselective 1,4-protoboration of dienylboronates provides unsymmetrical 1,4-bifunctional allylboron reagents. A subsequent chemoselective allylboration with aldehydes followed by oxidative workup give diol products with high diastereoselectivity. S. Gao, M. Wang, M. Chen, Org. Lett., 2018, 20, 7921-7925.
Synthesis of C2-C4 diols from bioresources: Pathways and …
WEBFeb 1, 2022 · Classical metabolic interventions bring about large enhancements in C2-C4 diol production, but the quick progress of potent genome sequencing techniques and protein manipulation techniques permit the construction of de novo developed synthetic routes for the synthesis of commercially important diols (Mori and Shirai, 2018). Since the ...
Production of C2–C4 diols from renewable bioresources: new …
WEBDec 13, 2017 · In this study, we review recent advances in bioproduction of C2–C4 diols, focusing on new metabolic pathways and metabolic engineering strategies being developed. We also discuss the challenges and future trends toward the development of economically competitive processes for bio-based diol production.
Synthesis of methanediol [CH2 (OH)2]: The simplest geminal diol | PNAS
WEBGeminal diols—organic molecules carrying two hydroxyl groups at the same carbon atom—have been recognized as key reactive intermediates by the physical (organic) chemistry and atmospheric science communities as fundamental transients in the aerosol cycle and in the atmospheric ozonolysis reaction sequence.