XRCC1 - Wikipedia
DNA repair protein XRCC1, also known as X-ray repair cross-complementing protein 1, is a protein that in humans is encoded by the XRCC1 gene. XRCC1 is involved in DNA repair, where it complexes with DNA ligase III.
XRCC1 protects transcription from toxic PARP1 activity during ... - Nature
Nov 22, 2021 · XRCC1 is a scaffold protein that is recruited to SSBs by PARP1 and/or PARP2 activity through direct interaction between poly (ADP-ribose) and the central BRCT domain in XRCC1 (refs. 8, 9, 10).
XRCC1 Gene - GeneCards | XRCC1 Protein | XRCC1 Antibody
Oct 2, 2024 · XRCC1 (X-Ray Repair Cross Complementing 1) is a Protein Coding gene. Diseases associated with XRCC1 include Spinocerebellar Ataxia, Autosomal Recessive 26 and Xeroderma Pigmentosum Group D . Among its related pathways are Base excision repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER) .
XRCC1 protein; Form and function - PubMed
XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase, DNA polymerase, DNA deadenylase, and DNA ligase activities that collectively are capable of accelerating the repair of a broad range of DNA single-strand breaks (SSBs).
XRCC1 X-ray repair cross complementing 1 [ (human)]
Oct 28, 2024 · XRCC1 is an HSP90 client protein that protects XRCC1 from proteasome-mediated degradation. Chinese Han people with rs1799782 TT/CT genotype of XRCC1 gene may have increased risk of developing colorectal.
XRCC1 mutation is associated with PARP1 hyperactivation and
Dec 21, 2016 · XRCC1 is a molecular scaffold protein that assembles multi-protein complexes involved in DNA single-strand break repair 1, 2. Here we show that biallelic mutations in the human XRCC1 gene are...
XRCC1 protein; Form and function - ScienceDirect
Sep 1, 2019 · XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase, DNA polymerase, DNA deadenylase, and DNA ligase activities that collectively are capable of accelerating the repair of a broad range of DNA single-strand breaks (SSBs).
XRCC1 - Strategies for coordinating and assembling a versatile …
X-ray cross complementing protein 1 (XRCC1) is a DNA repair scaffold that supports base excision repair and single strand break repair, and is also a participant in other repair pathways.
Temporal activation of XRCC1-mediated DNA repair is essential …
Jan 12, 2016 · Here, we identify the base excision repair pathway component XRCC1 as an indispensable mediator of muscle differentiation.
XRCC1 protein; Form and function - ScienceDirect
Sep 1, 2019 · XRCC1 is a molecular scaffold protein that interacts with multiple enzymatic components of DNA single-strand break repair (SSBR) including DNA kinase, DNA phosphatase, DNA polymerase, DNA deadenylase, and DNA ligase activities that collectively are capable of accelerating the repair of a broad range of DNA single-strand breaks (SSBs).