Th1 and Th2 responses: what are they? | The BMJ
WEBAug 12, 2000 · The Th2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE and eosinophilic responses in atopy, and also interleukin-10, which has more of an anti-inflammatory response. In excess, Th2 responses will counteract the Th1 mediated microbicidal action.
T helper cell - Wikipedia
WEBThe T helper cells ( Th cells ), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines.
Recent advances in understanding the Th1/Th2 effector choice
WEBMar 15, 2021 · Contributions of dendritic cell subsets in the initiation of classical and alternative differentiation pathways for the generation of Th1 and Th2 cells in vivo. Presented here is our updated view of the Th1/Th2 T effector decision in vivo.
Science commentary: Th1 and Th2 responses: what are they?
WEBAug 8, 2000 · The Th2-type cytokines include interleukins 4, 5, and 13, which are associated with the promotion of IgE and eosinophilic responses in atopy, and also interleukin-10, which has more of an anti-inflammatory response. In excess, Th2 responses will counteract the Th1 mediated microbicidal action.
Molecular Mechanisms of T Helper Cell Differentiation and …
WEBFeb 17, 2023 · For example, Th1 and Th17 cells plays critical roles in rheumatoid arthritis, type I diabetes, and multiple sclerosis; Th2 cells in allergic diseases such as asthma, rhinitis, and allergic dermatitis; and Treg cells in autoimmune disease, allergy, and cancer.
TH2 cell development and function | Nature Reviews Immunology
WEBOct 30, 2017 · T helper 2 (T H 2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory...
Helper T cells: Overview & Function - Cleveland Clinic
WEBJun 7, 2022 · TH1 helper cells release a molecule that activates a type of cell called a macrophage. Macrophages are specialized cells that help eliminate foreign substances from your body. TH1 cells also activate cytotoxic T cells. TH2 helper cells release molecules that activate B cells. B cells create antibodies.
TH1 and TH2 cells: a historical perspective - Nature
WEBJan 1, 2002 · In this article, I attempt to trace the historical events contributing to the development of the TH1/TH2 concept, the current state of play, and briefly discuss the future prospects for the...
Understanding the development and function of T follicular
WEBApr 12, 2010 · Th1 and Th2 lineages of CD4 + T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a (IgG2a) and IgG1/IgE, respectively.
Overview of T Cell Subsets | Immunopaedia
WEBThe pattern of cytokine expression defines the subsets of CD4+ T cells: Th1, Th2, Treg1, Th3, and Th17 cells. Th1 cells secrete interferon gamma (IFN-y) and create a milieu in which key cytotoxic effectors—macrophages, natural killer cells, and cytotoxic CD8+ T lymphocytes—are activated, generating cell-mediated immunity.