Snail-Family Proteins: Role in Carcinogenesis and Prospects for ...
SMAD proteins interact with the SNAI1 gene promoter and induce Snail expression, which leads to the repression of E-cadherin and an invasive phenotype . Upon TGF-β-induced EMT, Snail was shown to form a complex with SMAD3/4.
Central role of Snail1 in the regulation of EMT and resistance in ...
Aug 2, 2014 · Encoded by the SNAI1 gene located on human chromosome 20q13.2, Snail1 is composed of 264 amino acids and usually acts as a transcriptional repressor. Phosphorylation and nuclear localization of Snail1, governed by PI3K and Wnt signaling pathways crosstalk, are critical in Snail1’s regulation.
SNAI1 protein expression summary - The Human Protein Atlas
The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2.
The snail superfamily of zinc-finger transcription factors
Mar 1, 2002 · Abstract. The Snail superfamily of zinc-finger transcription factors is involved in processes that imply pronounced cell movements, both during embryonic development and in the acquisition...
SNAI2 gene - MedlinePlus
The SNAI2 gene (often called SLUG) provides the instructions for making a protein called snail 2. Snail 2 belongs to the snail protein family, which plays a role in the formation of tissues during embryonic development.
Entry - *604238 - SNAIL FAMILY TRANSCRIPTIONAL REPRESSOR 1; SNAI1 …
Jan 14, 2020 · While twist functions as a positive regulator of mesoderm-specific genes, snail acts as a boundary repressor by downregulating the expression of ectodermal genes within the mesoderm. Snail is a member of the Drosophila Snail family of proteins.
Characterisation of the human snail (SNAI1) gene and exclusion …
Here, we describe the isolation and characterisation of the human Snail (SNAI1) gene and a related Snail-like pseudogene, SNAI1P. SNAI1 spans approximately 6.4kb, contains three exons and has a CpG island upstream of the coding sequence.
The Snail genes as inducers of cell movement and survival
Here, we discuss these functions and how they influence cell behaviour during development and during diseases such as metastatic cancer. From these findings, we propose that Snail genes act primarily as survival factors and inducers of cell movement, …
The SNAIL1 promoter contains G-quadruplex structures regulating …
Sep 15, 2020 · In this study, we discovered the presence of G-quadruplex structures in the SNAIL1 gene promoter, and revealed their potential role in regulating SNAIL1 expression and its autonomous mutations in the human genome.
SNAI1 (snail homolog 1 (Drosophila)) - atlasgeneticsoncology.org
Aug 1, 2010 · The Snail gene in Drosophila (sna), first identified during analysis of dorso-ventral patterning, is a zinc finger gene with repressor function required for mesoderm formation (Boulay et al., 1987; Leptin, 1991).