SOCS3 - Wikipedia
WEBSuppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. [5][6] This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.
SOCS3, a Major Regulator of Infection and Inflammation
WEBFeb 19, 2014 · SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation.
SOCS3, a Major Regulator of Infection and Inflammation
WEBFeb 19, 2014 · SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation.
SOCS3 Gene - GeneCards | SOCS3 Protein | SOCS3 Antibody
WEBAug 6, 2024 · SOCS3 (Suppressor Of Cytokine Signaling 3) is a Protein Coding gene. Diseases associated with SOCS3 include Dermatitis, Atopic, 4 and Hematologic Cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Gene expression (Transcription).
The JAK1/STAT3/SOCS3 axis in bone development, physiology, …
WEBAug 13, 2020 · This review focuses specifically on the effects of skeletal JAK1, STAT3, and SOCS3, which transduce signals initiated by the IL-6 family cytokines that stimulate bone-forming cells...
SOCS3 as a future target to treat metabolic disorders - PubMed
WEBThe suppressors of cytokine signaling (SOCS) are a group of eight proteins responsible for preventing excessive cytokine signaling. Among this protein family, SOCS3 has received special attention. SOCS3 expression is important …
SOCS Proteins in Immunity, Inflammatory Diseases, and Immune …
WEBSep 16, 2021 · SOCS3 suppresses the inflammatory activities of macrophages by providing negative feedback regulation of inflammatory cytokines such as IL-6, IL-1β, and IL-12, with myeloid-specific SOCS3 knockouts showing enhanced and prolonged JAK/STAT signaling, increasing the levels of M1 pro-inflammatory genes .
SOCS proteins, cytokine signalling and immune regulation
WEBMay 18, 2007 · SOCS3 determines the different responses induced by the inflammatory cytokine interleukin-6 (IL-6) and the anti-inflammatory cytokine IL-10. In dendritic cells (DCs), SOCS1 negatively regulates T...
SOCS3 revisited: a broad regulator of disease, now ready for ...
WEBMay 3, 2016 · SOCS3 plays a significant role in regulating different signal transduction pathways, with the classical JAK/STAT regulation being the target of its effects. SOCS3 expression is shown to be associated with many inflammatory, immunological, infectious and oncogenic disorders.
SOCS3 is a suppressor of γc cytokine signaling and constrains
WEBSOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor-associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3-interaction motif, and then binds JAK molecules to inhibit their kinase activity ….