Nadal and Federer have played each other 40 times, with Nadal leading 24–16. They have the most Grand Slam finals between them, 12, with Nadal winning 10. They also have an all-time record 20 Grand Slam titles each. Their rivalry is considered one of the greatest in tennis history.
Nadal and Djokovic have played each other 56 times, with Djokovic leading 29–27. They have the most matches between them in the Open Era, as well as the most Grand Slam meetings, 16, with Nadal leading 10–6. They have faced each other in nine Grand Slam finals, with Djokovic winning five. They are the only pair to have completed the Career Grand Slam head-to-head.
Nadal and Murray have played each other 24 times, with Nadal leading 17–7. They have met in eight Grand Slam tournaments, with Nadal winning seven. They have also met in five Masters finals, with Nadal winning three. Murray is one of the few players to have beaten Nadal on all three major surfaces (hard, clay, and grass).
Nadal and Wawrinka have played each other 22 times, with Nadal leading 19–3. They have met in four Grand Slam tournaments, with Nadal winning three. They have also met in three Masters finals, with Nadal winning two. Wawrinka is one of the few players to have defeated Nadal in a Grand Slam final, at the 2014 Australian Open.
Nadal and del Potro have played each other 19 times, with Nadal leading 12–7. They have met in six Grand Slam tournaments, with Nadal winning four. They have also met in two Olympic Games, with del Potro winning the bronze medal match in 2012 and Nadal winning the gold medal match in 2016. Del Potro is one of the few players to have defeated Nadal in a Grand Slam semifinal, at the 2009 US Open.