Analysis of ROR1 Protein Expression in Human Cancer and …
Jun 15, 2017 · ROR1 is considered a promising target for cancer therapy due to putative tumor-specific expression, and multiple groups are developing antibodies and/or chimeric antigen receptor-modified T cells to target ROR1.
Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid …
Oct 12, 2021 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate comprising a monoclonal...
ROR1 Gene - GeneCards | ROR1 Protein | ROR1 Antibody
Oct 2, 2024 · ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are GPCR Pathway and ERK Signaling.
Receptor tyrosine kinase-like orphan receptor 1: A novel ... - PubMed
May 24, 2024 · Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and serves as a biomarker and therapeutic target.
Tyrosine Kinase ROR1 as a Target for Anti-Cancer Therapies
May 28, 2021 · Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is overexpressed in many types of malignant tumors. Studies have demonstrated that it plays an important role in oncogenesis by activating cell survival signaling events, particularly the non-canonical WNT signaling pathway.
ROR1 receptor tyrosine kinase like orphan receptor 1 [ (human)]
Oct 10, 2024 · This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors.
ROR1: an orphan becomes apparent | Blood - American Society of …
Oct 6, 2022 · Since its initial identification in 1992 as a possible class 1 cell-surface receptor without a known parent ligand, receptor tyrosine kinase–like orphan receptor 1 (ROR1) has stimulated research, which has made apparent its significance in embryonic development and …
ROR1, an embryonic protein with an emerging role in cancer …
ROR1 has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelial-mesenchymal transition (EMT). Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy.
Maintenance and pharmacologic targeting of ROR1 protein …
May 30, 2018 · Therefore, our work reveals a mechanism by which UHRF1 stabilizes ROR1, suggesting a potential targeting strategy to inhibit ROR1 in t(1;19) pre-B-ALL and other malignancies.
Antibody–drug conjugates for cancer score with ROR1 - Nature
Jan 11, 2021 · ROR1 is a receptor tyrosine kinase that is expressed primarily during embryogenesis, rather than in normal adult tissues. But various hematological and solid cancers upregulate ROR1...
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