A review of phenformin, metformin, and imeglimin - PubMed
Phenformin and metformin are biguanide antidiabetic agents that are conveniently synthesized in a single-step chemical reaction. Phenformin was once used to lower blood glucose levels, but later withdrawn from the market in several countries because it …
Phenformin: Uses, Interactions, Mechanism of Action | DrugBank …
Jun 13, 2005 · Used to treat diabetes, phenformin is a biguanide (contains 2 guanidino groups) hypoglycemic agent with actions and uses similar to those of metformin (Glucophage). Both drugs work by (1) decreasing the absorption of glucose by the intestines, (2) decreasing the production of glucose in the liver, and by (3) increasing the body's ability to use ...
Phenformin, But Not Metformin, Delays Development of T Cell …
Apr 16, 2019 · Vara-Ciruelos et al. now report that genetic loss of AMPK in T cells accelerates T cell acute lymphoblastic leukemia/lymphoma, whereas the biguanide phenformin, but not metformin, protects against its development in a cell-autonomous, AMPK-dependent manner.
Phenformin | C10H15N5 | CID 8249 - PubChem
Phenformin is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity. Phenformin is not used clinically due to the high risk of lactic acidosis that is associated with its use.
Phenformin - an overview | ScienceDirect Topics
Phenformin is a type 2 diabetes medication that belongs to the biguanide class and has shown promising anticancer activity, particularly in suppressing cell proliferation in various types of tumors such as ovarian, glioblastoma, colon, thyroid, and melanoma.
Phenformin activates ER stress to promote autophagic cell
May 8, 2024 · We found that phenformin suppresses OSCC cell proliferation, and promotes OSCC cell autophagy and apoptosis to significantly inhibit OSCC cell growth both in vivo and in vitro.
Direct effects of phenformin on metabolism/bioenergetics and …
Sep 14, 2017 · Phenformin, a member of the biguanides class of drugs, has been reported to be efficacious in cancer treatment. The focus of the current study was to establish whether there were direct effects of phenformin on the metabolism and bioenergetics of neuroblastoma SH-SY5Y cancer cells.
Phenformin as an Anticancer Agent: Challenges and Prospects
Jul 5, 2019 · Chemotherapeutic agents are used in the treatment of cancer, but in most cases, patients develop resistance. Phenformin, an oral biguanide drug used to treat type 2 diabetes mellitus, was removed from the market due to a high risk of fatal lactic acidosis.
The Mechanism of Action of Biguanides: New Answers to a …
Jun 30, 2022 · Phenformin (1-(diaminomethylidene)-2-(2-phenylethyl)guanidine) is a phenethyl biguanide derivative of metformin that is characterized by the substitution of one of the terminal nitrogen atoms with a 2-phenylethyl group. Phenformin is obtained by heating phenethylamine and cyanoguanidine (37% yield) .
Phenformin | SpringerLink
Improves glucose tolerance in patients with type 2 diabetes and affects both postprandial and basal plasma glucose levels. It improves insulin sensitivity by decreasing hepatic glucose production, decreasing intestinal glucose absorption, and enhancing peripheral glucose uptake, predominantly in muscle and liver.
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