Phosphoglycerate kinase - Wikipedia
Phosphoglycerate kinase (EC 2.7.2.3) (PGK 1) is an enzyme that catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to ADP producing 3-phosphoglycerate (3-PG) and ATP : 1,3-bisphosphoglycerate + ADP ⇌ glycerate 3-phosphate + ATP. Like all kinases it is a transferase.
Nature子刊：浙大易文组揭示肿瘤生长新机制：代谢酶PGK1糖基 …
磷酸甘油酸激酶1（phosphoglycerate kinase 1，PGK1）是糖酵解途径中的关键代谢酶，它催化1,3-二磷酸甘油酸（1,3-BPG）转化为3-磷酸甘油酸（3-PG）并产生糖酵解途径中的第一个ATP。PGK1在多种癌细胞中有高水平的表达；最近的研究表明，PGK1与肿瘤的发生和发展密切相关。
Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target …
Sep 1, 2020 · Phosphoglycerate kinase 1 (PGK1) is the first critical enzyme to produce ATP in the glycolytic pathway. PGK1 is not only a metabolic enzyme but also a protein kinase, which mediates the tumor growth, migration and invasion through phosphorylation some …
PGK1 Gene - GeneCards | PGK1 Protein | PGK1 Antibody
Oct 2, 2024 · PGK1 (Phosphoglycerate Kinase 1) is a Protein Coding gene. Diseases associated with PGK1 include Phosphoglycerate Kinase 1 Deficiency and Nonaka Myopathy. Among its related pathways are glycolysis (BioCyc) and Gluconeogenesis. Gene Ontology (GO) annotations related to this gene include phosphoglycerate kinase activity.
Phosphoglycerate kinase 1 acts as a cargo adaptor to promote …
Feb 3, 2024 · The epidermal growth factor receptor (EGFR) plays important roles in cell growth and motility. Here, authors reveal an unexpected function for a metabolic enzyme PGK1 and advance the mechanistic...
Hypoxia-induced downregulation of PGK1 crotonylation promotes ...
Aug 12, 2024 · Our findings show that PGK1 Kcr is a signal in coordinating glycolysis and the tricarboxylic acid (TCA) cycle and may serve as a diagnostic indicator for breast cancer.
磷酸甘油酸激酶 - 维基百科，自由的百科全书
Apr 6, 2024 · 磷酸甘油酸激酶 (英文名:Phosphoglycerate kinase，简称PGK)（ EC 2.7.2.3 ) (PGK 1) 是一种 酶，可催化磷酸基团从 1,3-二磷酸甘油酸 (1,3-BPG) 到 ADP 的 可逆 转移，产生 3-磷酸甘油酸 (3-PG) 和 ATP ：. 1,3-二磷酸甘油酸 + ADP ⇌ 3-磷酸甘油酸 + ATP. 与所有 激酶 一样，它是一种 转移 ...
Abstract. Phosphoglycerate kinase 1 (PGK1) is the first key metabolic enzyme to produce ATP during glyco-lysis and is involved in the glycolysis pathway of tumors. PGK1 can not only affect tumor growth as a metabolic enzyme, but also affect gene expression, energy metabolism, molecular regulation and. *通讯作者。.
Phosphoglycerate Kinase 1: An Effective Therapeutic Target in …
Mar 6, 2024 · Phosphoglycerate kinase 1 (PGK1) serves as a pivotal enzyme in the cellular glycolysis pathway, facilitating adenosine-triphosphate (ATP) production in tumor cells and driving the Warburg effect. PGK1 generates ATP through the reversible phosphorylation reaction of 1,3-bisphosphoglycerate (1,3-BPG) ….
The basic functions of phosphoglycerate kinase 1 and its roles in ...
Apr 5, 2022 · Phosphoglycerate kinase 1 (PGK1) is an essential enzyme that catalyzes adenosine 5'-triphosphate (ATP) production in aerobic glycolysis. In addition to regulating cell metabolism, PGK1 is involved in multiple biological activities, including angiogenesis, mediated autophagy starting, binding of plas ….
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