p53 - Wikipedia
WEBp53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in …
p53 - 维基百科，自由的百科全书
WEBp53是一系列被称为腫瘤抑制蛋白（也稱為p53蛋白或p53腫瘤蛋白）的同源异构蛋白的统称。由TP53（人体）及Trp53（老鼠）基因编码。该蛋白是最早发现的肿瘤抑制基因所编码的蛋白之一。
p53的功能、结构和修饰| Abcam中文官网
WEBp53 是一种肿瘤抑制蛋白和转录因子，可调控细胞分裂，阻止 DNA 突变或受损的细胞进行分裂并通过转录调控向这些细胞传导凋亡信号，从而阻止肿瘤形成。. 它可以对细胞应激或 DNA 损伤作出响应，激活多种转录靶标。. p53 可协调多种反应，包括细胞周期阻滞、DNA ...
p53基因 - 百度百科
WEBP53正常功能的丧失，最主要的方式是基因突变，通过 肿瘤 中大量的突变体分 析，证实大部分突变是位于4个 突变热点 之一的 错义突变。. 这4个突变热点是aa129～146、 …
Tumor suppressor p53: Biology, signaling pathways, and ... - PubMed
WEBTP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered. The p53 pathway is a complex cellular stress response network with ….
Targeting p53 pathways: mechanisms, structures, and advances in …
WEBMar 1, 2023 · The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and …
Tumor Suppressor p53: Biology, Signaling Pathways, and …
WEBFeb 23, 2022 · TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles in development, aging and cell differentiation [2].
The multiple mechanisms that regulate p53 activity and cell fate
WEBMar 1, 2019 · The tumour suppressor p53 has a central role in the response to cellular stress. Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple...
p53: A tale of complexity and context - Cell Press
WEBMar 28, 2024 · We know now that p53 can orchestrate a plethora of biological processes and cell states, including multiple key metabolic pathways, different DNA repair processes, stem cell modulation, aging, development, fertility, and still others. Likewise, p53’s role in cell death is not limited only to apoptosis.
Nature Reviews | p53：一种蛋白质，众多靶点 - 知乎
WEBp53肿瘤抑制蛋白是防止癌症发生和发展的一个主要障碍。 在生物化学上，p53主要作为一种序列特异性的转录因子，能够与基因组内确定的DNA序列（称为p53反应元件或p53结合位点）结合并激活相邻基因的转录，以及由具有p53结合位点的增强子调节的更远的基因的转录。 此外，p53还可以抑制一大批基因的转录，通常是通过间接机制。 在正常未受压的细胞中，p53蛋白水平通过构成性蛋白体降解保持在较低水平，该降解由E3泛素连接酶MDM2 …
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