p21 - Wikipedia
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
Multiple functions of p21 in cell cycle, apoptosis and ... - PubMed
In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles in p21 expression and activity.
Multiple functions of p21 in cell cycle, apoptosis and ...
Jun 1, 2016 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis.
p21 in cancer: intricate networks and multiple activities - PMC
The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an effector of multiple anti-proliferative signals.
p21 in Cancer Research - PMC - PubMed Central (PMC)
Aug 14, 2020 · p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is dysregulated in some cancers. Earlier observations on p21 knockout models emphasized the role of this protein in cell cycle arrest under the p53 transcription factor activity.
p21: A Two-Faced Genome Guardian: Trends in Molecular Medicine …
Mar 6, 2017 · p21 is a two-faced regulator depending on cell type, cellular localization, p53 status, and the type and level of genotoxic stress. It can acquire either oncosuppressive or oncopromoting properties depending on whether it is in a p53-proficient or p53-deficient environment, respectively.
Biology of the cell cycle inhibitor p21(CDKN1A): molecular ... - PubMed
The main, well-known function of p21 is to arrest cell cycle progression by inhibiting the activity of cyclin-dependent kinases. In addition, p21 is involved in the regulation of transcription, apoptosis, DNA repair, as well as cell motility.
p21 in cancer: intricate networks and multiple activities
May 14, 2009 · The cyclin-dependent kinase inhibitor p21 (also known as p21 WAF1/Cip1) promotes cell cycle arrest in response to many stimuli. It is well positioned to function as both a sensor and an...
p21 shapes cancer evolution | Nature Cell Biology
Jun 28, 2016 · Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers.
p21 | SpringerLink
Jan 1, 2017 · The p21 gene is a transcriptional target for multiple proliferation-inhibitory signaling cascades, including p53 (which can be activated in response to DNA damage), TGF (transforming growth factor beta), TNF (tumor necrosis factor alpha), IFN (interferon gamma), or APC (adenomatosis polyposis coli). p21 binds to the DNA polymerase subunit PCNA ...