KSHV (HHV8) vaccine: promises and potential pitfalls for a new …
Sep 20, 2022 · Kaposi sarcoma herpesvirus (KSHV or HHV8) is the sole cause of Kaposi sarcoma, which primarily afflicts resource-poor and socially marginalized populations. This review summarizes a...
KSHV (HHV8) vaccine: promises and potential pitfalls for a new …
Sep 20, 2022 · This review summarizes a recent NIH-sponsored workshop's findings on the epidemiology and biology of KSHV as an overlooked but potentially vaccine-preventable infection. The unique epidemiology of this virus provides opportunities to prevent its cancers if an effective, inexpensive, and well-tolerated vaccine can be developed and delivered.
A multivalent Kaposi sarcoma-associated herpesvirus-like particle ...
Jul 7, 2019 · In this study, we generated a novel subunit vaccine that incorporates four key KSHV envelope glycoproteins required for viral entry in diverse cell types (gpK8.1, gB, and gH/gL) into a single multivalent KSHV-like particle (KSHV-LP).
The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL …
Feb 26, 2020 · Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS), one of the most prevalent cancers of people living with HIV/AIDS in sub-Saharan Africa. The seroprevalence for KSHV is high in the region, and no prophylactic vaccine against the virus is available.
RFA-CA-24-006: Translational Research Toward Development of a …
Oct 16, 2023 · A therapeutic KSHV vaccine could be helpful in preventing or treating KSHV disease in people already infected with KSHV. The U01 research projects funded through this NOFO will form a cooperative group, the KSHV Vaccine Development Consortium (KVDC).
JCI - Kaposi sarcoma–associated herpesvirus: immunobiology, …
Sep 1, 2016 · We would argue that KSHV vaccine development is needed, and that both preventative and therapeutic KSHV vaccines would be of benefit. KSHV transmission among infants is similar to that of all other herpesviruses; by puberty, greater than 80% of children seroconvert in KSHV endemic regions.
Designing a multi-epitope based vaccine to combat Kaposi …
Feb 21, 2019 · The present study was aimed to design a multi-epitope based vaccine targeting the major glycoproteins of KSHV which plays an important role in the virus entry.
KSHV | The Chang-Moore Lab Cancer Virology Program
Jun 11, 2024 · There is no vaccine for KSHV and there is little commercial interest from vaccine or drug manufacturers at present in developing them. Because this virus appears to be under exquisite control by the immune system, it should be a …
KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic ...
Infection of mice with murine γ-herpesvirus 68 (MHV-68) has been exploited as an experimental model to explore proof-of-principle vaccination strategies, such as MHV-68 subunit vaccines targeting lytic and latency-associated viral proteins, heat-inactivated MHV-68 virions and MHV-68 replication-deficient viruses.
KSHV (HHV8) vaccine: promises and potential pitfalls for a new …
Sep 20, 2022 · KSHV vaccines for low- and middle-income countries (LMIC) The development of an effective vaccine candidate that can prevent KSHV infection and onward transmission or prevent secondary tumorigenesis after infection is a tractable scientific problem.