Interleukin 11 - Wikipedia
Interleukin 11 (IL-11 or adipogenesis inhibitory factor [5]) is a protein that in humans is encoded by the IL11 gene. [6] IL-11 is a cytokine that was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells.
Anti-aging drug extends life up to 25%, staves off frailty and disease
Jul 18, 2024 · Anti-IL-11 therapy boosted metabolism, with the animals producing calorie-burning brown fat, not problematic stores of white fat, blocked the loss of muscle mass and strength, and...
Anti-inflammatory drug extended the lifespan of mice by 20 per cent
Jul 17, 2024 · Blocking an inflammatory molecule known as interleukin-11 (IL-11) extends the lifespan of mice, suggesting that drugs inhibiting IL-11 may have anti-ageing effects in people, too.
Interleukin-11: Review of Molecular, Cell Biology, and Clinical …
Jun 1, 1997 · Interleukin-11 stimulates the proliferation of human hematopoietic CD34+ and CD34+CD33−DR− cells and synergizes with stem cell factor, interleukin-3, and granulocyte-macrophage colony-stimulating factor.
Blocking Inflammation Protein Extends Lifespan
Jul 17, 2024 · Treatment with anti-IL-11 from 75 weeks of age until death extends the median lifespan of male mice by 22.5% and of female mice by 25%. Together, these results demonstrate a role for the pro-inflammatory factor IL-11 in mammalian healthspan and lifespan.
Scientists identify interleukin-11 as key driver of aging
Jul 17, 2024 · The team demonstrated in preclinical models that the protein interleukin-11 (IL-11) actively promotes aging and that giving an anti-IL-11 therapy not only counteracts the deleterious effects...
Breakthrough in Anti-Aging: IL-11 Deactivation Boosts
Jul 30, 2024 · Inhibiting IL-11 in mice extends lifespan and reduces aging signs, with potential implications for human aging treatments. Researchers from the Medical Research Council Laboratory of Medical Science and Imperial College London have discovered that ‘switching off’ a protein called IL-11 can increa
Interleukin 11 therapy causes acute left ventricular dysfunction
6 days ago · Interleukin 11 (IL11) was initially thought important for platelet production, which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 was later found to be redundant for haematopoiesis and its use in patients is associated with unexplained and severe cardiac side effects. Here we aim to identify, for the first ...
Understanding interleukin 11 as a disease gene and therapeutic …
Dec 6, 2023 · Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is redundant for haematopoiesis and toxic.
Interleukin-11 and its eminent role in tissue fibrosis: a possible ...
Sep 19, 2023 · Inhibiting interleukin 11 signaling reduces hepatocyte death and liver fibrosis, inflammation, and steatosis in mouse models of nonalcoholic steatohepatitis.