Interleukin 21 - Wikipedia
WEBInterleukin 21 (IL-21) is a protein that in humans is encoded by the IL21 gene. [5] [6] [7] Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.
我是两面派，↓ B 细胞，↑T 细胞——IL21 － 丁香通
WEBSep 1, 2017 · IL-21 是作用于 B 细胞的一类免疫抑制因子, 可以抑制 B 细胞淋巴瘤细胞亚群的增殖, IL-21 也可能在调节 B 细胞肿瘤发生方面具有作用。. IL-21 在鼠的原始 B 细胞可诱导 Stat1 和 Stat3 的磷酸化. Stat3 在变异细胞的增殖和存活中起关键作用, 而 Stat1 则是一种肿 …
Interleukin-21: a double-edged sword with therapeutic potential
WEBApr 22, 2014 · Interleukin-21 is a cytokine with broad pleiotropic actions that affect the differentiation and function of lymphoid and myeloid cells. Since its discovery in 2000, a tremendous amount has been ...
肿瘤治疗多效细胞因子——IL21 - 知乎 - 知乎专栏
WEB肿瘤治疗多效细胞因子——IL21. 细胞因子是调节各种免疫反应的重要因素，在疾病的诱导、起始、进展和减轻中起着关键作用。. 因此，确定细胞因子调节疾病状态的机制有助于设计新的治疗方法。. 其中，白介素IL21（Interleukin 21）是主要的免疫调节剂之一，通过 ...
IL-21 Signaling in Immunity - PMC - National Center for …
WEBFeb 26, 2016 · IL-21 is a type I cytokine produced by T cells and natural killer T cells that has pleiotropic actions on a wide range of immune and non-immune cell types. Since its discovery in 2000, extensive studies on the biological actions of IL-21 have been performed in vitro and in vivo.
IL-21及其受体在自身免疫性疾病中的作用 - PMC
WEBMay 5, 2016 · 研究发现，白细胞介素21（interleukin-21, IL-21）是Ⅰ型细胞因子γ链（γc）家族中的新型细胞因子，主要由活化的CD4 + T细胞和自然杀伤T（natural killer T, NKT）细胞合成和分泌。IL-21具有广泛的生物学调节功能，这些功能的发挥依赖于IL-21和IL-21受体（receptor, R）结合 ...
The IL-21/IL-21R signaling axis regulates CD4 + T-cell …
WEB1. Introduction. As a member of the common gamma-chain (γc) signaling family of cytokines, IL-21 plays critical roles in the regulation of various biological functions such as proliferation, development, and function/differentiation of both the innate and adaptive arms of the immune system. 1–3 IL-21 is a pleiotropic cytokine expressed by CD4 + T cells, …
IL-21: a pleiotropic cytokine with potential applications in oncology
WEBInterleukin- (IL-) 21 is a pleiotropic cytokine that regulates the activity of both innate and specific immunity. Indeed, it costimulates T and natural killer (NK) cell proliferation and function and regulates B cell survival and differentiation and the function of dendritic cells.
Interleukin 21: combination strategies for cancer therapy
WEBMar 1, 2008 · Here, we provide an overview of the antitumour effects of IL21 and describe strategies to combine IL21 with other drugs for future cancer therapies.
IL-21：多效细胞因子，在肿瘤治疗、病毒感染、过敏反应中终将“ …
WEBNov 26, 2021 · 其中，白介素IL-21（Interleukin-21）是主要的免疫调节剂之一，通过影响多种免疫细胞来调节各种免疫应答。. IL-21能增强免疫细胞的抗原特异性反应，促进T细胞和NK细胞的抗肿瘤活性，在B细胞分化和生发细胞发育中起着关键作用，表明IL-21可能是开发肿瘤免疫疗法 ...
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