Immunology of IL-12: An update on functional activities and
WEBDec 11, 2020 · As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells.
Interleukin-12: Functional activities and implications for disease
WEBInterleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-γ production in T and NK cells.
Immunology of IL-12: An update on functional activities and ...
WEBDec 11, 2020 · As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells.
Localized Interleukin-12 for Cancer Immunotherapy - PubMed
WEBOct 15, 2020 · Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans.
Interleukin-12 and the regulation of innate resistance and ... - Nature
WEBFeb 1, 2003 · Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours the ...
Interleukin-12: an update on its immunological activities, signaling ...
WEBInterleukin-12 (IL-12) is a heterodimeric cytokine composed of the p35 and p40 subunits. It is produced by antigen-presenting cells and plays a critical role in host defense against intracellular microbial infection and control of malignancy via its ability to stimulate both innate and adaptive immune effector cells.
Interleukin 12 - an overview | ScienceDirect Topics
WEBInterleukin 12 (IL-12), a cytokine that stimulates T-helper anti-tumor immune responses, could prove beneficial as a therapy in treating cancer. However, the systemic administration of IL-12 might cause serious health side effects.
IL-12 family cytokines: immunological playmakers - Nature
WEBJul 19, 2012 · The interleukin 12 (IL-12) family is unique in having the only heterodimeric cytokines, including IL-12, IL-23, IL-27 and IL-35.
IL-12 and IL-23 cytokines: from discovery to targeted ... - Nature
WEBJun 29, 2015 · The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–mediated responses in inflammation for more than a decade after it was first identified.
IL-12 Family Cytokines in Cancer and Immunotherapy - PMC
WEBJan 6, 2021 · The IL-12 family cytokines are known to play essential roles in regulating innate and adaptive immune responses [1]. The functions of the IL-12 family cytokines have been widely studied in the settings of infection and auto-inflammatory diseases.
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