Oct 24, 2023 · ⱡ For On-X mechanical valves, ASA 81mg daily should be added to VKA both initially after AVR placement and when INR goal is reduced to 1.5—2.0 after 3 months of therapy. ASA – Aspirin, AVR – Aortic Valve Replacement, DAPT – Dual Antiplatelet Therapy, DOAC – Direct Oral Anticoagulant, OAC – Oral Anticoagulation,