IL-12p40: an inherently agonistic cytokine - PubMed
IL-12p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form. Its most widely appreciated function is to provide a negative feedback loop by competitively binding to the IL-12 receptor.
IL-12 and IL-23 cytokines: from discovery to targeted ... - Nature
Jun 29, 2015 · In mice and humans, IL-12 is composed of the IL-12p40 subunit linked to the IL-12p35 subunit, and the heterodimer signals through the IL-12 receptor (IL-12R), which comprises the IL-12Rβ1...
IL-12p40: an inherently agonistic cytokine - Cell Press
IL-12p40 is known as a component of the bioactive cytokines interleukin (IL)-12 and IL-23 but it is not widely recognized as having intrinsic functional activity. Recent publications have altered this perception and support an independent role for IL-12p40.
Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis ...
The focus of this review, however, is on the enigmatic Interleukin 12 (IL-12) family of cytokines. This family of cytokines plays crucial roles in shaping immune responses during antigen presentation and influence cell-fate decisions of differentiating naïve T cells.
The IL-12 family of cytokines in infection, inflammation and
IL-27 and IL-23 are two cytokines that are related to IL-12; these cytokines share homology at the subunit, receptor, and signalling levels. IL-12 is composed of p35 and p40 subunits, which, when combined together form the bioactive IL-12p70.
A novel cytokine consisting of the p40 and EBI3 subunits ... - Nature
Nov 15, 2021 · The interleukin (IL)-12 cytokine family is closely related to the development of T helper cells, which are responsible for autoimmune disease enhancement or suppression. IL-12 family...
Immunology of IL-12: An update on functional activities and ...
Dec 11, 2020 · As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells.
IL-12p40 Monomer: A Potential Player in Macrophage Regulation
While the functions of p40 monomer are not known, by using a specific mAb, recently, we have delineated the selective upregulation of p40 monomer, but not that of IL-12, IL-23, and p40 homodimer, in the serum of prostate cancer and breast cancer patients compared with healthy controls [20, 21].
IL-12p40 is induced in excess over the other subunits of IL-12 and IL-23 and can exist in a monomeric or homodimeric form. Its most widely appreciated function is to provide a negative feedback loop by competitively binding to the IL-12 receptor.
Regulation of IL-12p40 by HIF controls Th1/Th17 responses to
Jan 25, 2017 · We observed selective induction of IL-12p40 following PHDi-treatment, concurrent with suppression of Th1 and Th17 responses in murine colitis models.
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