Hemozoin - Wikipedia
Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin. In malaria parasites, hemozoin is often called malaria pigment.
Hemozoin - an overview | ScienceDirect Topics
Hemozoin is a heme polymer that is produced as a byproduct of the heme detoxification system in malaria. The repetitive life cycle of the parasite in the blood leads to accumulation of hemozoin in macrophages, leukocytes and tissues, and to continuous targeting by the host innate immune system.
Hemozoin in malaria eradication—from material science, …
Dec 22, 2023 · Here, we present a comprehensive perspective on state-of-the-art hemozoin-based methodologies for detecting and studying malaria. We discuss the challenges (and opportunities) to...
Hemozoin: a Complex Molecule with Complex Activities
Apr 11, 2021 · Hemozoin (HZ) is an insoluble, iron-containing waste product of Plasmodium produced during the parasite’s intraerythrocytic digestion of hemoglobin. As infection progresses, HZ can be observed within several organs and has been correlated with disease severity (reviewed by [7]).
Evidence for a role of hemozoin in metabolism and …
Aug 1, 2017 · The prominent interaction of hemozoin with several antimalarial drugs, the involvement of proteins in hemozoin formation, and the finding of plasmodial genes coding for a heme-oxygenase-like protein argue for a wider and more active role for hemozoin in the parasite’s metabolism.
The structure of malaria pigment β-haematin | Nature
Mar 16, 2000 · The haem groups released from the digestion of the haemoglobin of infected red blood cells are aggregated into an insoluble material called haemozoin or malaria pigment.
Hemozoin and antimalarial drug discovery - PMC - National …
One such high-throughput screening effort has been focused on hemozoin formation, a unique heme detoxification pathway found in the malaria parasite. This review discusses the current approaches and limitations of high-throughput screening discovery of hemozoin inhibitors.
Hemozoin - SpringerLink
Dec 23, 2016 · Hemozoin (malaria pigment, β-hematin) is the chemically inert crystalline substance produced in the digestive food vacuole of blood-stage malaria parasites. The pigment is visible microscopically in intraerythrocytic stages that are actively degrading hemoglobin.
Hemozoin: a Complex Molecule with Complex Activities
Heme released by hemoglobin catabolism is modified by the parasite to produce hemozoin (HZ), which has toxic effects on the host. Experimentation aiming to elucidate how HZ contributes to malaria pathogenesis has utilized different preparations of this molecule, complicating interpretation and comparison of findings.
Haemozoin formation - ScienceDirect
Feb 1, 2008 · Recent advances in our understanding of the formation of haemozoin, both from new observations that it is formed within lipid bodies in P. falciparum and S. mansoni and biomimetic studies on the formation of its synthetic counterpart β-haematin are reviewed.