Hypoxia-inducible factor - Wikipedia
WEBHIF-1, when stabilized by hypoxic conditions, upregulates several genes to promote survival in low-oxygen conditions. These include glycolysis enzymes, which allow ATP synthesis in an oxygen-independent manner, and vascular endothelial growth factor (VEGF), which promotes angiogenesis .
HIF1A - Wikipedia
WEBHypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine …
Hypoxia-Inducible Factor (HIF)-1 Regulatory Pathway and its ...
WEBHypoxia-Inducible Factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body's response to low oxygen concentrations, or hypoxia. HIF-1 is among the primary genes involved in the homeostatic process, which can increase vascularization in hypoxic areas such as localized ischemia and tumors.
Biology of HIF-1α | Cell Death & Differentiation - Nature
WEBFeb 15, 2008 · HIF-1 α controls metabolic and pH-regulating pathways. Cells respond to hypoxia by HIF-1 α -mediated upregulation of glucose transporters (Glut-1 and Glut-3) and enzymes of glycolysis ...
HIF-1 α pathway: role, regulation and intervention for cancer ...
WEBJun 6, 2015 · Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. This review summarizes the role and regulation of the HIF-1α in cancer and recent therapeutic approaches targeting this important pathway.
Hypoxia-Inducible Factor-1α: The Master Regulator of ...
WEBJan 13, 2020 · Wei H., Bedja D., Koitabashi N., Xing D., Chen J., Fox-Talbot K., Rouf R., Chen S., Steenbergen C., Harmon J.W., et al. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of …
Hypoxia Inducible Factor 1 - an overview | ScienceDirect Topics
WEBHypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis by mediating a wide range of cellular and systemic adaptive physiological responses to reduced oxygen availability.
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