The Role of GPNMB in Inflammation - PubMed
May 12, 2021 · GPNMB, an endogenous glycoprotein, has been recently related to inflammation and neuroinflammation. GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively.
GPNMB Gene - GeneCards | GPNMB Protein | GPNMB Antibody
Oct 1, 2024 · GPNMB (Glycoprotein Nmb) is a Protein Coding gene. Diseases associated with GPNMB include Amyloidosis, Primary Localized Cutaneous, 3 and Lichen Amyloidosis. Among its related pathways are Signaling by PTK6 and Signal Transduction. Gene Ontology (GO) annotations related to this gene include heparin binding and integrin binding.
The Role of GPNMB in Inflammation - Frontiers
May 12, 2021 · GPNMB, an endogenous glycoprotein, has been recently related to inflammation and neuroinflammation. GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively.
GPNMB: a potent inducer of immunosuppression in cancer
Sep 1, 2022 · Glycoprotein-NMB (GPNMB) is a transmembrane glycoprotein that is overexpressed in a variety of cancers. It can promote primary tumor growth and metastasis, and GPNMB expression correlates with...
The soluble glycoprotein NMB (GPNMB) produced by …
Jul 29, 2020 · GPNMB triggers in the cancer cells the formation of self-renewing spheroids, which are characterized by the expression of cancer stem cell markers, prolonged cell survival and increased...
The glycoprotein GPNMB attenuates astrocyte inflammatory …
Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that releases a soluble signaling peptide when cleaved by ADAM10 or other extracellular proteases.
Glycoprotein nonmetastatic melanoma protein B: a key …
The glycoprotein nonmetastatic melanoma protein B (GPNMB, also known as osteoactivin) is highly expressed in many cell types and regulates the homeostasis in various tissues. In different physiological contexts, it functions as a ...
Glycoprotein non-metastatic b (GPNMB): A metastatic mediator …
GPNMB, initially termed glycoprotein non-metastatic gene B (NMB), was first cloned and described in 1995 as a protein highly expressed in a melanoma cell line with low metastatic potential. 38 However, since this initial publication, elevated GPNMB expression is observed in numerous cancers and is often associated with the metastatic phenotype ...
GPNMB: a potent inducer of immunosuppression in cancer
Glycoprotein-NMB (GPNMB) is a transmembrane glycoprotein that is overexpressed in a variety of cancers. It can promote primary tumor growth and metastasis, and GPNMB expression correlates with poor prognosis and shorter recurrence-free survival in patients.
GPNMB glycoprotein nmb [Homo sapiens (human)] - Gene - NCBI
Aug 17, 2024 · GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential.
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