GAB2 - Wikipedia
WEBGAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell.
GAB2 Gene - GeneCards | GAB2 Protein | GAB2 Antibody
WEBAug 6, 2024 · GAB2 (GRB2 Associated Binding Protein 2) is a Protein Coding gene. Diseases associated with GAB2 include Achard Syndrome and Developmental And Epileptic Encephalopathy 12. Among its related pathways are Insulin receptor signalling cascade and FLT3 signaling in disease.
Structure and function of Gab2 and its role in cancer (Review)
WEBJun 17, 2015 · Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, cytokines and antigen receptors.
Gab2 (Grb2-Associated Binder2) Plays a Crucial Role in ...
WEBApr 8, 2021 · Gab2 (Grb2-associated binder2) silencing or deficiency inhibits TNFα (tumor necrosis factor alpha)-induced, IL (interleukin)-1β–induced, or lipopolysaccharide (LPS)-induced proinflammatory responses in endothelial cells.
GAB2 - A Scaffolding Protein in Cancer - PMC
WEBGAB2 is essential for two major signal transduction pathways in cancer, thePI3K-AKT and ERK signaling pathways, and thus regulates a number of key cellular processes. This review focuses on structure and function of GAB2, its regulatory proteins, emerging role in cancer, and potential as a therapeutic target.
Gab2 deficiency prevents Flt3-ITD driven acute myeloid ...
WEBDec 13, 2021 · Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations.
GAB2--a scaffolding protein in cancer - PubMed
WEBGAB2 is essential for two major signal transduction pathways in cancer, the PI3-K-AKT and extracellular signal-regulated kinase (ERK) signaling pathways, and thus regulates a number of key cellular processes.
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