『珍藏版』Science综述 | 整合应激反应——从机制到复杂疾病 - 知乎
整合应激反应 （integrated stress response ISR）是蛋白质稳态失调时诱发的信号中心调控网络，主要以控制蛋白质合成速率来实现。. 2020年4月24日，美国贝勒医学院的 Mauro Costa-Mattioli 和UCSF大学的 Peter Walter 在 Science 上发表题为 The integrated stress response: From mechanism to ...
GCN2 kinase activation by ATP-competitive kinase inhibitors
Dec 23, 2021 · A genome-wide CRISPR screen revealed that loss of general control nonderepressible 2 (GCN2) kinase increases cellular resistance to the pan-ErbB inhibitor neratinib with neratinib directly...
Multiple Roles of the Stress Sensor GCN2 in Immune Cells
The serine/threonine-protein kinase general control nonderepressible 2 (GCN2) is a well-known stress sensor that responds to amino acid starvation and other stresses, making it critical to the maintenance of cellular and organismal homeostasis.
GCN2和mTORC1信号路径对动物机体氨基酸平衡的调节作用
Sep 1, 2017 · GCN2 signaling pathway can effectively sense intracellular AA starvation, mTORC1 signaling pathway can respond to the change of extracellular AA level. Combining with the recent studies regarding GCN2 and mTORC1, this review summarized characteristics of the GCN2 and mTORC1 signaling pathways and the related response mechanism under the ...
Science子刊：揭示GCN2抑制肿瘤微环境中的抗肿瘤免疫反应
Dec 25, 2019 · 虽然GCN2是免疫肿瘤学中的一种潜在的治疗靶点，但是它在塑造 肿瘤 免疫反应中的作用尚不清楚。. 在一项新的研究中，来自加拿大、美国、巴西和 ...
GCN2: roles in tumour development and progression - PMC
Apr 4, 2022 · GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. Recently, there has been renewed interest in GCN2 as a potential oncotarget, with several studies reporting the development of small molecule inhibitors.
GCN2 controls the cellular checkpoint: potential target for …
Feb 14, 2018 · In a recent report published in Nature, Ravindran et al. demonstrated that GCN2-mediated amino acid starvation-sensing mechanisms can shape intestinal inflammation in the dextran sodium sulfate...
GCN2: roles in tumour development and progression - PubMed
Apr 29, 2022 · GCN2 (general control nonderepessible 2) is an eIF2α kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. Recently, there has been renewed interest in GCN2 as a potential oncotarget, with several studies reporting the development of s ….
GCN2 contributes to mTORC1 inhibition by leucine deprivation …
Jun 14, 2016 · In order to assess the idea that GCN2 contributes to the rapid modulation of mTORC1 activity specifically by leucine, we took advantage of the ability of total amino acid deprivation to inhibit...
Global phosphoproteomics pinpoints uncharted Gcn2-mediated …
May 6, 2021 · The Gcn2 kinase mediates cellular adaptations to amino acid limitation through the translational control of gene expression that is primarily executed by eIF2α phosphorylation.