Danon Disease: Causes & Outlook - Cleveland Clinic
Feb 22, 2024 · Danon disease is a lysosomal storage disorder. It’s an genetic condition that affects people in many ways, most often damaging their heart, muscles and brain. Contents Overview Symptoms and Causes Diagnosis and Tests Management and Treatment Prevention Outlook / Prognosis Additional Common Questions.
Danon disease - Wikipedia
Danon disease (or glycogen storage disease Type IIb) is a metabolic disorder. [1] Danon disease is an X-linked lysosomal and glycogen storage disorder associated with hypertrophic cardiomyopathy, skeletal muscle weakness, and intellectual disability. [2] It is inherited in an X-linked dominant pattern. [1]
Danon Disease - Symptoms, Causes, Treatment | NORD
Feb 9, 2023 · Danon disease is a rare genetic disorder characterized by an X-linked dominant inheritance pattern, so males are more severely affected than females.
Danon disease - MedlinePlus
Danon disease is a condition characterized by weakening of the heart muscle (cardiomyopathy); weakening of the muscles used for movement, called skeletal muscles (myopathy); and intellectual disabilities. People with Danon disease may develop the condition at different ages.
Danon Disease - Boston Children's Hospital
Danon disease is a rare inherited disorder that affects many organ systems, especially the cardiovascular, skeletal, and central nervous systems. The condition is one of about 50 lysosomal storage disorders (LSD) in which genetic variations disrupt the …
Understanding Danon Disease
Danon Disease is a rare, genetic condition characterized by a mutation or deletion of the LAMP2 (short for lysosome-associated membrane protein) gene located on the X chromosome. It can be either inherited from a parent with the condition or a new genetic change (‘de novo’).
Glycogen storage disease due to LAMP-2 deficiency
Glycogen storage disease due to LAMP-2 deficiency (Danon disease) is a rare genetic condition characterized by weakening of the heart muscle (cardiomyopathy), weakening of the muscles used for movement (skeletal muscles myopathy), and intellectual disability.
Danon Disease: Practice Essentials, Pathophysiology, Epidemiology
Danon disease is also known as lysosomal glycogen-storage disease with normal acid maltase. Danon disease is a rare form of HCM and muscular dystrophy. Signs and symptoms of Danon disease....
Gene Therapy for Danon Disease - Children's Hospital of Philadelphia
What is Danon disease? Danon disease is a rare genetic disorder that affects several tissues and organ systems in the body. It is a type of lysosomal storage disease (LSD). Lysomal storage diseases occur when the body doesn’t have the necessary protein cells to properly metabolize and recycle waste (an intracellular process called autophagy).
Living with Danon Disease
Danon Disease is a lifelong disease and there is no cure. Currently, only treatments are available to help with symptoms and underlying issues; Danon Disease presents itself differently, person-by-person. Some have symptoms daily, others may experience them once a week, and some people may not have symptoms at all. Danon Disease can also ...