Integrin alpha-1 - Wikipedia
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others. [5]
CD49a Expression Defines Tissue-Resident CD8 - PubMed
Feb 21, 2017 · Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8 + Trm cells on a compartmental and functional basis. In human skin epithelia, CD8 + CD49a + …
CD49a Expression Defines Tissue-Resident CD8 - National …
Feb 2, 2017 · CD49a constitutes the α-subunit of the α 1 β 1 integrin receptor, also known as very late antigen 1 (VLA-1), and binds collagen IV enriched in the basement membrane separating epidermis and dermis.
Differential expression of CD49a and CD49b determines …
CD49a-expressing subpopulations express elevated CD69 in an antigen-independent manner. CD49a has been described as a marker of T RM cells, together with PD-1 and CD69 (42,43). Consequently, we evaluated CD69 expression on subpopulations in conjunction with their expression of Nur77.
CD49a Regulates Cutaneous Resident Memory CD8 - Cell Press
Sep 1, 2020 · CD49a regulates T RM dendritic morphology and response to antigen challenge. Summary. CD8 + tissue-resident memory T cells (T RM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge.
CD49a Regulates Cutaneous Resident Memory CD8 - PubMed
Sep 1, 2020 · CD8 + T RM expressing the α1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and in vitiligo lesions. We demonstrate that CD49a is expressed early following T cell activation in vivo, and TGF-β and IL-12 induce CD49a expression by CD8 + T cells in vitro.
CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that …
Sep 9, 2021 · DP and CD49a CD8 memory T cell subsets are polyfunctional. Heat maps show the transcriptional differences between the four T cell subsets (A) and the clusters based on protein staining for Lamp-1, CCL1, IFNγ, TNF, IL-2, Granzyme A, and Perforin after 6 hours of in vitro stimulation; heat map (B).
Charting cellular identity during human in vitro β-cell ... - Nature
May 8, 2019 · We implement a scalable re-aggregation technique to deplete non-endocrine cells and identify CD49a (also known as ITGA1) as a surface marker of the β-cell population, which allows magnetic...
Differential Expression of CD49a and CD49b Determines
Here, we found that tumor-infiltrating CD8 + T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth. This differentiation sequence was driven by antigen-independent elements in the TME, although T-cell receptor (TCR) stimulation further increased CD49a expression.
CD4+ T cell help during early acute hepacivirus infection is critical ...
5 days ago · CD103+CD49a+ T cells were preferentially retained in the liver, showed increased INF-γ and TNF-α production and had the capacity to directly mediate viral clearance in vivo. They also persisted as long-term Trm cells in the liver indicating that these cells may play an important role in protective immunity to hepacivirus infection.
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