Cdk7: a kinase at the core of transcription and in the ... - PubMed
Cdk7, associated with the transcription initiation factor TFIIH, is both an effector CDK that phosphorylates Pol II and other targets within the transcriptional machinery, and a CDK …
Cdk7: a kinase at the core of transcription and in the crosshairs of ...
Cdk7 functions during the Pol II transcription cycle.Cdk7 acts at multiple points during progression through the Pol II transcription cycle. These functions can be direct effects of Cdk7-mediated …
Cyclin-dependent kinase 7 (CDK7) inhibitors as a novel …
Feb 14, 2024 · Cyclin-dependent kinase (CDK) 7 is aberrantly overexpressed in many types of cancer and is an attractive target for cancer therapy due to its dual role in transcription and cell …
Emerging roles of cyclin-dependent kinase 7 in health and diseases
Oct 15, 2024 · Cyclin-dependent kinase 7 (CDK7) is the catalytic subunit of CDK-activating kinase (CAK), which phosphorylates CDK1/2/4/6 and RNA polymerase II (Pol II) to promote cell cycle …
CDK inhibitors in cancer therapy, an overview of recent …
CDK7 has dual functions of cell cycle controlling and transcriptional regulation, which make CDK7 a potential target for cancer therapy. Several CDK7 specific inhibitors have been shown …
Inhibition of the transcriptional kinase CDK7 overcomes therapeutic ...
Aug 28, 2019 · CDK7 promotes cell cycle progression through inhibition of transcription, rather than via direct phosphorylation of classical CDK targets. The transcriptional kinase activity of …
CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?
Jul 23, 2020 · Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed …
Structural basis of Cdk7 activation by dual T-loop phosphorylation …
Aug 3, 2024 · Cyclin-dependent kinase 7 (Cdk7) is a master regulator of cell cycle progression and gene expression, by virtue of its ability to phosphorylate the activation segment, or T loop, …
Selective inhibition of CDK7 reveals high-confidence targets and …
Using SILAC-based phosphoproteomics with transcriptomics and biochemical assays, the authors identified high-confidence CDK7 substrates, a surprisingly widespread requirement for CDK7 …
The Mediator captures CDK7, an attractive transcriptional target in ...
Sep 13, 2021 · Recent efforts to develop small molecule inhibitors that target cyclin-dependent kinase 7 (CDK7) have suggested that CDK7 may play a critical role in mediating the …
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