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    CD2 - Wikipedia

    CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. See more

    Function

    It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells.
    In addition to its … See more

    Classification

    Due to its structural characteristics, CD2 is a member of the immunoglobulin superfamily; it possesses two immunoglobulin-like domains in its extracellular portion. See more

    External links

    • CD2+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
    • Mouse CD Antigen Chart
    • Human CD Antigen Chart
    • Human CD2 genome location and CD2 gene details page in the See more

    Overview image
    Interactions

    CD2 has been shown to interact with CD2BP2, Lck and PSTPIP1. See more

    Further reading

    • Sayre PH, Reinherz EL (1989). "Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review". Scand. J. … See more

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  2. Frontiers
    https://www.frontiersin.org › journals › im…

    CD2 Immunobiology - Frontiers

    Jun 8, 2020 · CD2 is a costimulatory receptor expressed on T and NK cells that binds to LFA3 on antigen-presenting cells. This article reviews the structure, function and clinical applications of CD2 and its pathway in …

    Tags:
    CD2 Immunobiology
    Immunological synapse
  3. GeneCards
    https://www.genecards.org › cgi-bin › car…

    CD2 Gene - GeneCards | CD2 Protein | CD2 Antibody

    Oct 1, 2024 · CD2 is a protein coding gene that encodes a surface antigen on T-cells and other immune cells. It interacts with LFA3 and CD48 to mediate adhesion and signaling. Find aliases, disorders, pathways, products, and …

    Tags:
    CD2 Molecule
    Protein
  4. People also ask
    What does CD2 stand for?
    Eukaryotic Human Cluster Of Differentiation 2 (CD2) Recombinant Human Cluster Of Differentiation 2 (CD2) BPS Bioscience Proteins for CD2 CD2, Avi-His-Tag, Biotin-Labeled HiP™ Recombinant CD2, Avi-His-Tag HiP™ Recombinant CD2, Fc fusion, Avi-Tag, (Human) HiP™ Recombinant

    CD2 Gene - GeneCards | CD2 Protein | CD2 Antibody

    genecards.org
    Is CD2 a transmembrane molecule?
    CD2 is a transmembrane molecule and a member of the immunoglobulin supergene family and binds CD58, CD48, and CD59 [5, 44, 45]. The existence of this molecule was originally discovered by the ability of human T-cells to spontaneously bind sheep erythrocytes (E-rosette receptor) [5, 40].

    CD2 - an overview | ScienceDirect Topics

    sciencedirect.com
    What is a CD2 receptor?
    The CD2 receptor family is within the immunoglobulin (Ig) superfamily and consists of type 1 transmembrane proteins with an N-terminal variable Ig domain followed by a constant two Ig domain (Sidorenko and Clark, 2003). You might find these chapters and articles relevant to this topic.

    CD2 - an overview | ScienceDirect Topics

    sciencedirect.com
    Does CD2 co-stimulator enhance IL-2 production from first-generation chimeric antigen receptor T cells?
    Ligation of the CD2 co-stimulatory receptor enhances IL-2 production from first-generation chimeric antigen receptor T cells. Gene Therapy. (2012) 19:1114–20. doi: 10.1038/gt.2011.192 156. Hanada K, Bagadia P, Wang Q, Griffith K, Yang J. Augmenting adoptive T cell therapy through universal chimeric costimulators.

    CD2 Immunobiology - Frontiers

    frontiersin.org
    Is CD2 a costimulatory molecule?
    The results of increased positive selection upon CD2-deletion for a low-affinity model TCR are surprising, given the opposite role of CD2 in the periphery, however independent studies have made similar findings for other costimulatory molecules such as CD5 and CD28 (102, 103).

    CD2 Immunobiology - Frontiers

    frontiersin.org
    What are the aliases for CD2 gene cards?
    Aliasesfor CD2 Gene Aliases for CD2 Gene GeneCards Symbol:CD22 CD2 Molecule235 SRBC345 CD2 Antigen (P50), Sheep Red Blood Cell Receptor23 T-Cell Surface Antigen T11/Leu-534

    CD2 Gene - GeneCards | CD2 Protein | CD2 Antibody

    genecards.org
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  6. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    CD2 Immunobiology - PubMed

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    CD2 Immunobiology
    Cd2 Protein Immune Synapse
    Cd2 LFA3
  7. ScienceDirect
    https://www.sciencedirect.com › topics › neuroscience

    CD2 - an overview | ScienceDirect Topics

    Tags:
    CD2 Molecule
    Cd2 Nk Cells
    Cd2 Family

  8. Explore CD2

  9. Nature
    https://www.nature.com › articles

    A dynamic CD2-rich compartment at the outer edge of the

    Tags:
    Cd2 Protein Immune Synapse
    Immunological synapse
    Cd2 Expression in Melanoma
  10. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    The structural biology of CD2 - PubMed

    Tags:
    CD2 Molecule
    Lymphocyte Cd2
    Cd2 Biology Review
    Cd2 Structure
  11. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    The CD2 family of natural killer cell receptors - PubMed

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    Cd2 Nk Cells
    Cd2 Function
    Cd2 Family
    Natural killer cell
    Cd3- Nk Cells
  12. UniProt
    https://www.uniprot.org › uniprot

    UniProt

    Tags:
    Lymphocyte Cd2
    Cd2 Function
  13. ScienceDirect
    https://www.sciencedirect.com › topics › immunology-and-microbiology

    CD2 - an overview | ScienceDirect Topics

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    Protein
    CD2