C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. [5] . Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19 /ELC) and (C-C motif) ligand 21 (CCL21). [6] .

Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance.

It is activated by two different ligands, CCL19 and CCL21, and is responsible for the proper recruitment of lymphocytes and mature DCs to lymphoid tissues. Several chemokine receptors including CCR7 have been identified in chicken [186], and their expression in isolated CD4+ T cells from blood and various tissues were investigated [199].

CC‑chemokine receptor 7 (CCR7) is well known to direct adaptive immune cell migration to secondary lymphoid tissues (Fig. 3) [44]. CCR7 is expressed by various lymphocytes, including dendritic cells, B cells, and T cells.

Jan 15, 2001 · We find that CCR7 is expressed on the vast majority of peripheral blood T cells, including most cells that express adhesion molecules (cutaneous lymphocyte Ag α 4 β 7 integrin) required for homing to nonlymphoid tissues.

Growing evidence suggests that cell trafficking orchestrated by the C-C chemokine receptor 7 (CCR7) plays a critical role in the pathophysiology of several leukemias and lymphomas.

Dec 24, 2024 · CCR7 (C-C Motif Chemokine Receptor 7) is a Protein Coding gene. Diseases associated with CCR7 include Chronic Graft Versus Host Disease and Pars Planitis. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Chemokine receptors promote chemotaxis of cells and tissue organization. Since under homeostatic conditions, CCR7 promotes migration of immune cells to lymph nodes, questions immediately arose regarding the ability of CCR7 to direct migration of …

Recent evidence suggests that by guiding cells to and within lymphoid organs, CC-chemokine receptor 7 (CCR7) essentially contributes to both immunity and tolerance.

May 1, 2023 · Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells and peripheral immune cells, and plays an important role in regulating behavior in homeostasis and neuroinflammation in disease.