- Pregnancy / Lactation
Information regarding use in pregnancy or lactation is lacking. At 4 to 5 weeks' gestation, nicotinic receptor proteins and gene transcripts for nicotinic receptor subunits ex… See more
Drugs.com
- Cytisine is a plant-based alkaloid that has been studied for its potential benefits. In vitro studies suggest neuronal protective effects of cytisine through mechanisms that involve downregulation of N-methyl-D-aspartate (NMDA) receptors1. Limited studies in rodents have reported efficacy in treating induced depression1. Cytisine has a short half-life of 4.8 hours and provides smokers with satisfaction similar to smoking a cigarette, alleviating the urge to smoke and reducing the severity of nicotine withdrawal symptoms, while also reducing the reward experience of any cigarettes smoked2.Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.In vitro studies suggest neuronal protective effects of cytisine through mechanisms that involve downregulation of N-methyl-D-aspartate (NMDA) receptors. Li 2013 Limited studies in rodents have reported efficacy in treating induced depression. Treatment with cytisine for 2 weeks relieved symptoms related to unpredictable chronic mild stress.www.drugs.com/npp/cytisine.htmlCytisine has a short half-life of 4.8 hours. As a result, the extract provides smokers with satisfaction similar to smoking a cigarette, alleviating the urge to smoke and reducing the severity of nicotine withdrawal symptoms, while also reducing the reward experience of any cigarettes smoked.en.wikipedia.org/wiki/Cytisine
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First large U.S. clinical trial of cytisinicline finds the smoking ...
Cytisinicline (historically known as cytisine) is a naturally occurring plant-based alkaloid that binds selectively to nicotinic receptors in the brain that regulate nicotine dependence, alleviating the …
Cytisine versus Nicotine for Smoking Cessation | NEJM
Dec 18, 2014 · Placebo-controlled trials indicate that cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6...
Cytisine for smoking cessation: A systematic review and meta …
Oct 1, 2023 · This is a comprehensive review on cytisine vs. placebo, varenicline, and NRT for smoking cessation. Cytisine is likely more effective than placebo and NRT with more side …
E-cigarettes, varenicline and cytisine are the most ... - Cochrane
Sep 12, 2023 · Comprehensive study reveals nicotine e-cigarettes, varenicline and cytisine are the stop-smoking aids most likely to help people quit smoking. On average, for every 100 …
Cytisine, the world’s oldest smoking cessation aid | The …
Aug 23, 2013 · Nearly 50 years ago, and before any smoking cessation aids were approved in the Western world, cytisine was being used in eastern and central Europe to help people quit smoking. An alkaloid with high affinity for the α4β2 …
Cytisinicline for Smoking Cessation - JAMA Network
Importance Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to α4β2 nicotinic acetylcholine receptors, which mediate nicotine dependence. Although not licensed in the US, cytisinicline is used in some …
The safety, effectiveness and cost‐effectiveness of cytisine in ...
May 30, 2018 · Cytisine, if proven effective, can offer a cheaper alternative to other cessation aids. Furthermore, because cytisine is a plant‐based medication, adherence may be better …
E-cigarettes, Varenicline and Cytisine are the Most Effective Stop ...
Sep 12, 2023 · A comprehensive new analysis has found that nicotine e-cigarettes, varenicline and cytisine are the most effective options currently available for helping smokers quit long …
Efficacy of cytisine in helping smokers quit: systematic ... - Thorax
Conclusions Cytisine is an effective treatment for smoking cessation with efficacy comparable to that of other currently licensed treatments. Given its low cost and potential for public health …
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