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- Cytisine is a plant-based alkaloid that has been studied for its potential benefits. In vitro studies suggest neuronal protective effects of cytisine through mechanisms that involve downregulation of N-methyl-D-aspartate (NMDA) receptors1. Limited studies in rodents have reported efficacy in treating induced depression1. Cytisine has a short half-life of 4.8 hours and provides smokers with satisfaction similar to smoking a cigarette, alleviating the urge to smoke and reducing the severity of nicotine withdrawal symptoms, while also reducing the reward experience of any cigarettes smoked2.Learn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.In vitro studies suggest neuronal protective effects of cytisine through mechanisms that involve downregulation of N-methyl-D-aspartate (NMDA) receptors. Li 2013 Limited studies in rodents have reported efficacy in treating induced depression. Treatment with cytisine for 2 weeks relieved symptoms related to unpredictable chronic mild stress.www.drugs.com/npp/cytisine.htmlCytisine has a short half-life of 4.8 hours. As a result, the extract provides smokers with satisfaction similar to smoking a cigarette, alleviating the urge to smoke and reducing the severity of nicotine withdrawal symptoms, while also reducing the reward experience of any cigarettes smoked.en.wikipedia.org/wiki/Cytisine
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Cytisine versus Nicotine for Smoking Cessation | NEJM
Dec 18, 2014 · Placebo-controlled trials indicate that cytisine, a partial agonist that binds the nicotinic acetylcholine receptor and is used for smoking cessation, almost doubles the chances of quitting at 6...
Cytisine for smoking cessation: A systematic review and meta …
E-cigarettes, varenicline and cytisine are the most ... - Cochrane
Cytisine, the world’s oldest smoking cessation aid | The …
Aug 23, 2013 · Nearly 50 years ago, and before any smoking cessation aids were approved in the Western world, cytisine was being used in eastern and central Europe to help people quit smoking. An alkaloid with high affinity for the α4β2 …
Cytisinicline for Smoking Cessation - JAMA Network
Importance Cytisinicline (cytisine) is a plant-based alkaloid that, like varenicline, binds selectively to α4β2 nicotinic acetylcholine receptors, which mediate nicotine dependence. Although not licensed in the US, cytisinicline is used in some …
The safety, effectiveness and cost‐effectiveness of cytisine in ...
E-cigarettes, Varenicline and Cytisine are the Most Effective Stop ...
Efficacy of cytisine in helping smokers quit: systematic ... - Thorax
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