TXNIP: A key protein in the cellular stress response pathway and a ...
Jul 3, 2023 · Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its...
TXNIP Gene - GeneCards | TXNIP Protein | TXNIP Antibody
Oct 2, 2024 · TXNIP (Thioredoxin Interacting Protein) is a Protein Coding gene. Diseases associated with TXNIP include Leukostasis and Hyperglycemia . Among its related pathways are Inflammasomes and Gene expression (Transcription) .
TXNIP in Metabolic Regulation: Physiological Role and …
TXNIP acts as an important regulator of glucose and lipid metabolism through pleiotropic actions including regulation of β-cell function, hepatic glucose production, peripheral glucose uptake, adipogenesis, and substrate utilization.
The role of TXNIP in cancer: a fine balance between redox
Oct 4, 2023 · Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent...
TXNIP: A key protein in the cellular stress response pathway and a ...
Jul 3, 2023 · TXNIP activates endoplasmic reticulum (ER) stress-mediated nucleotide-binding oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome complex formation, triggers mitochondrial stress-induced apoptosis, and …
Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and ...
As TXNIP can be expressed by neurons, microglia, astrocytes, and endothelial cells, a complex pattern of regulation and function in the brain is suggested. We will examine data suggesting TXNIP as a therapeutic target for neurodegenerative diseases where further research is needed.
TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook
Thioredoxin-interacting protein (TXNIP) was originally named vitamin D 3 upregulated protein-1 (VDUP1) because of its ability to bind to thioredoxin (TRX) and inhibit TRX function and expression. TXNIP is an alpha-arrestin protein that is essential for redox homeostasis in …
TXNIP thioredoxin interacting protein [ (human)] - National …
Oct 28, 2024 · TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis. Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality.
Role of Thioredoxin-Interacting Protein in Diseases and Its …
Mar 9, 2021 · Thioredoxin-interacting protein (TXNIP), widely known as thioredoxin-binding protein 2 (TBP2), is a major binding mediator in the thioredoxin (TXN) antioxidant system, which involves a reduction-oxidation (redox) signaling complex and is pivotal for the pathophysiology of some diseases.
TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis
Aug 18, 2020 · Both the redox-dependent and -independent TXNIP functions serve as regulatory pathways in glucose metabolism. This review highlights the key advances in understanding TXNIP function as a master regulator for whole-body glucose homeostasis.
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