1. Sepsis

    Medical Condition
    • Sepsis is a potentially life-threatening condition caused by the body's response to an infection. The body normally releases chemicals into the bloodstream to fight an infection. Sepsis occurs when the body's response to these chemicals is out of balance, triggering changes that can damage multiple organ systems.If sepsis progresses to septic shock, blood pressure drops dra…
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    • Sepsis is a life-threatening condition that requires early detection and timely, appropriate interventions to improve the chances of survival for patients of all ages. Sepsis is defined as a clinical syndrome in which patients have an infection that is accompanied by an extreme systemic response. Sepsis of sufficient severity that the function of major organ systems in the body (suc…
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    • To be diagnosed with sepsis, you must have a probable or confirmed infection and all of the following signs: 1. Change in mental status 2. A first (upper) number in a blood pressure reading — also called the systolic pressure — that's less than or equal to 100 millimeters of mercury (mm Hg) 3. Respiratory rate higher than or equal to 22 breaths a minute...
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    • Sepsis is a medical emergency. However, because of the characteristics of sepsis as a disease condition with multiple causative organisms and its evolving nature over time, people with sepsis can present various signs and symptoms at different times. Warning signs and symptoms include fever or low temperature and shivering, altered mental status, difficulty breathing/rapid breathin…
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    • In the early stages of a lower UTI, you may feel: 1. Sudden and extreme urges to void (pass urine) 2. Frequent urges to void 3. Burning, irritation or pain as you void 4. A feeling of not emptying your bladder completely 5. A feeling of pressure in your abdomen or lower back 6. Thick or cloudy urine – it may contain bloodAs the infection progresses, you may experience: 1. Fever 2. Pain i…
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    • There are three stages of sepsis: sepsis, severe sepsis, and sepsis shock. Early signs of sepsis may include a fever above 101 degrees or below 96.8 degrees Fahrenheit, a heart rate higher than 90 beats per minute, and a breathing rate above 20 breaths per minute.
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    • While any type of infection — bacterial, viral or fungal — can lead to sepsis, the most likely varieties include: 1. Pneumonia 2. Infection of the digestive system (which includes organs such as the stomach and colon) 3. Infection of the kidney, bladder and other parts of the urinary system 4. Bloodstream infection (bacteremia)
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    • Many different microbes can cause sepsis. Although bacteria are most commonly the cause, viruses and fungi can also cause sepsis. Infections in the lungs (pneumonia), bladder and kidneys (urinary tract infections), skin (cellulitis), abdomen (such as appendicitis), and other areas (such as meningitis) can spread and lead to sepsis. Infections that develop after surgery can also lea…
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    • The most common cause of sepsis is a bacterial infection in the bloodstream, also known as bacteremia. Bacteremia will sometimes go away by itself, or it can lead to sepsis if the immune system fails to remove the bacteria. The infection can begin anywhere bacteria enters the body; it can even result from something as seemingly innocent as a scraped knee. That said, sepsis ca…
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    • Sepsis happens when an infection spreads and causes your child's body to react strongly to germs. Your child's defense system normally releases chemicals to fight off infection at the infected area. When infection spreads, chemicals are released throughout your child's body. The chemicals cause inflammation and clotting in small blood vessels. The clots are often hard to co…
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    • When caught early, it is usually quite easy to treat a bacterial UTI effectively. After confirming that you do have an infection (usually through a simple examination of a urine sample), you would be prescribed antibiotics to fight the particular bacteria causing the infection. You also would be encouraged to drink a lot of water, to help flush out the infection.If your doctor suspects that the …
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    • During the first step of sepsis treatment, the doctor will typically run tests to check for a number of things: bacteria in the blood, excessive acid in the blood, a low platelet count, or an altered white blood cell count. Typical treatment for sepsis includes intravenous therapy to maintain blood pressure, oxygen to maintain adequate blood oxygen levels, and antibiotics to kill the bacteria c…
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    • Seek care immediately for any of the following: Several treatments may be needed if sepsis causes one or more organs to stop working correctly. Treatments are often started in the emergency room and continued in an intensive care or critical care unit of a hospital. Your child may need any of the following:
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    • \"When sepsis occurs, it should be treated as a medical emergency,\" said CDC Director Tom Frieden, M.D., M.P.H., in a news release(www.cdc.gov). \"Doctors and nurses can prevent sepsis and also the devastating effects of sepsis, and patients and families can watch for sepsis and ask, 'Could this be sepsis?'\" According to agency officials, health care professionals, including famil…
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    • There are two main steps to preventing sepsis: 1. prevention of microbial transmission and infection 2. prevention of the evolution of an infection to sepsis conditions.Prevention of infection in the community involves using effective hygiene practices, such as hand washing, and safe preparation of food, improving sanitation and water quality and availability, providing access to v…
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    • UTIs can be prevented in almost all cases. 1. When women wipe themselves after having a bowel movement, they must wipe from front to back, reducing the chances of stool touching the entrance of the urethra. The same thing must be done by caregivers if they are cleaning someone else. 2. After having sex, clean your genital area as the act of sex could push bacteria into the urethra. …
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    • Sepsis can be prevented by preventing infections, according to the CDC. Vaccinations help prevent the flu, pneumonia and other infections. Practicing cleanliness is the best way to prevent bacterial, viral or fungal infections. Always clean cuts and scrapes, wash hands regularly and bathe often. Additional resources 1. CDC: Sepsis guide 2. National Health Service: Septic shoc…
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    • Sepsis is caused by the body’s reaction to infectious pathogens. Therefore, preventative treatment focuses on eliminating infections that would trigger that kind of reaction from your body. Basic hygiene, such as good handwashing habits and cleaning of wounds, is one of the easier courses of action. This includes using antibiotic creams or sanitizers on wounds and hands, cov…
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    • Identifying and not underestimating the signs and symptoms listed above, along with the detection of some biomarkers (such as procalcitonin), are crucial elements for early diagnosis of sepsis and the timely establishment of its appropriate clinical management. After early recognition, diagnostics to help identify a causal pathogen of infection leading to sepsis are also important t…
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    • In the hospital, the doctor may conduct various tests. These tests will either be geared toward the patient's specific symptoms (for example, a chest X-ray if the patient is suspected of having pneumonia) or many different tests if the source of the sepsis is not known.
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    • 1. Acute Pancreatitis 2. Diabetic Ketoacidosis (DKA) 3. Lower Gastrointestinal Bleeding 4. Myocardial Infarction 5. Overzealous diuresis 6. Pulmonary Embolism (PE) 7. Upper Gastrointestinal Bleeding (UGIB)
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    • The CDC and other health officials are targeting a number of key areas related to sepsis by working to...
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    • Sepsis and septic shock are more common if you: 1. Are very young or very old 2. Have a compromised immune system 3. Have diabetes or cirrhosis 4. Are already very sick, often in a hospital intensive care unit 5. Have wounds or injuries, such as burns 6. Have invasive devices, such as intravenous catheters or breathing tubes 7. Have previously received antibiotics or corti…
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    • Everybody is potentially at risk of developing sepsis from minor infections. However, some people are more vulnerable, including people who: 1. have a medical condition that weakens their immune system – such as HIV or leukaemia 2. are receiving medical treatment that weakens their immune system – such as chemotherapy or long-term steroids 3. are very young or very old 4. …
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    • Its also important to note that particular complications and risk factors will increase the risk of sepsis, especially in the elderly. An increased sepsis risk in the elderly can result from chronic conditions, including cancer, HIV/AIDS, diabetes, and obesity.
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    • Male gender and increased age are associated with a greater risk of acquiring sepsis.1,2,7 The rate of infection rises with increasing length of ICU stay and worsening degree of organ failure.3 TABLE 1 lists predictors of mortality in sepsis patients.1-3...
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    Sepsis is a life-threatening condition in which the body is fighting a severe infection that has spread via the bloodstream. If a patient becomes \"septic,\" they will likely have low blood pressure leading to poor circulation and lack of blood perfusion of vital tissues and organs. This condition is termed \"shock\" and is sometimes refe…
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    • Its estimated that 28% to 50% of sepsis patients will die. The chances a person will survive septic shock depend on the number of organs affected or that have failed, and how soon you begin treatment. Septic shock complications can include abnormal blood clotting, kidney failure or injury, heart failure, and respiratory failure.
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    • Severe sepsis causes between 36,000 and 64,000 deaths annually in the UK, with a mortality rate of 35%. Mortality increases to over 40% in the presence of septic shock. There is also evidence that sepsis can have a longer-term effect, worsening the outcome of patients who have chronic diseases.Early effective treatment is crucial. One study found that each hour of delay in antibioti…
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    • Of the 246 adult patients included in the chart review, 65 (26 percent) died during their sepsis hospitalization. Of the 79 pediatric patients whose medical records were reviewed, 17 (22 percent) died while hospitalized for sepsis.
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    • To comprehend sepsis, a basic understanding of several terms is necessary. Bacteremia is simply the presence of bacteria in the blood.4 Systemic inflammatory response syndrome(SIRS) is denoted by two or more of the following clinical symptoms:(1) body temperature >38°C or <36°C; (2) heart rate >90 beatsper minute; (3) respiratory rate >20 breaths per minute or PaCO2 (partia…
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    • Blood poisoning, also known as septicemia or sepsis, occurs when the bloodstream becomes infected by bacteria (i.e., staphylococci, streptococci) or fungi introduced through a wound, abscess , or other injury. Septicemia may also originate from a localized infection in the body.
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    In the process, widespread inflammation is also triggered, which leads to leaky vessels and blood clotting. As a result, blood flow is impaired, and the bodys organs are damaged and deprived of oxygen and nutrients.
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    • The hallmark of sepsis is derangement in physiology. This may include: 1. Abnormal coagulation. 2. Endothelial cell dysfunction. 3. Presence of excessive tumour necrosis factor. 4. Cell apoptosis - eg, lymphocytes and endothelial cells. 5. Neutrophil hyperactivity. 6. Poor glycaemic control. 7. Lack of steroid hormones. 8. Cytokines, proteases, lipid mediators, gaseous substances, vasoa…
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  2. Sepsis in children: Know the signs - Children's Health

  3. Pediatric Sepsis > Fact Sheets - Yale Medicine

  4. Sepsis - Children's Hospital of Philadelphia

    Sepsis usually begins as a serious infection, but can progress to an emergency quickly (sometimes over hours). Although most symptoms are not specific for sepsis, there are several warning signs that may signal the presence of …

  5. Sepsis - Symptoms & causes - Mayo Clinic

  6. Sepsis in Infants & Children - HealthyChildren.org

    Sep 11, 2017 · Be Alert to the Signs & Symptoms of Sepsis: Detecting sepsis early and starting immediate treatment is often the difference between life and death. Parents and caregivers must seek immediate medical care if they …

  7. Children | Sepsis Alliance

    Updated March 27, 2024. Neonatal Sepsis. Sepsis in Older Children. Treatment. Prevention. Sepsis and Measles. Sepsis can affect anyone at any time, but children, particularly premature babies and infants, can be particularly prone.

  8. Sepsis in children - Symptoms, diagnosis and …

    Sep 19, 2024 · Sepsis in children may present initially with non-specific, non-localised symptoms (especially in younger age groups). Therefore it is important to have a low threshold for suspecting sepsis as the initial clinical presentation …

  9. Symptoms of sepsis - NHS

  10. Sepsis - World Health Organization (WHO)

    May 3, 2024 · Common signs of sepsis include fever, fast heart rate, rapid breathing, confusion and body pain. It can lead to septic shock, multiple organ failure and death. Sepsis is usually caused by bacterial infections but may be …

  11. About Sepsis | Sepsis | CDC - Centers for Disease Control and …