Open links in new tab
  1. All images
    See more images of Interleukin 12
    All images
    Wikipedia
    https://en.wikipedia.org › wiki

    Interleukin 12 - Wikipedia

    • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and … See more

    SymbolIL12B
    Alt. symbolsCLMF2, NKSF2, p40
    NCBI gene3593
    HGNC5970
    Gene and structure

    IL12 is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis. IL12A is composed … See more

    Functions

    IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN … See more

    Wikipedia text under CC-BY-SA license
    Feedback
     
  1. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Interleukin-12: Functional activities and implications for disease

  2. Nature
    https://www.nature.com › articles

    IL-12 family cytokines: immunological playmakers - Nature

  3. Studies of Il-12
    PubMed
    Interleukin-12: Functional activities and implications for disease
    Interleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-Îł production i...
    Author: Sebastian Zun…
    Published: 2015/10
    Keywords: Autoimmun…
    PubMed
    Immunology of IL-12: An update on functional activities and implications for disease
    As its first identified member, Interleukin-12 (IL-12) named a whole family of cytokines. In response to pathogens, the heterodimeric protein, consisting of the two subunits p35 and p40, is secreted by phagocytic cells. Binding of IL-12 to the IL-12 receptor (IL-12R) on T and natural killer (NK) cel...
    Author: Karen A-M Ullr…
    Published: 2020/12/11
    Keywords: IL-12; STA…
    PubMed
    Localized Interleukin-12 for Cancer Immunotherapy
    Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable antitumor efficacy in preclinical models has yet to be replicated in humans. Early clinical trials in the mid-1990's showed that ...
    Author: Khue G Nguyen
    Published: 2020/10/15
    Keywords: cancer imm…
    National Center for Biotechnology Information
    Interleukin 12 (IL-12) Family Cytokines: Role in Immune Pathogenesis and Treatment of CNS Autoimmune Disease
    Cytokines play crucial roles in coordinating the activities of innate and adaptive immune systems. In response to pathogen recognition, innate immune cells secrete cytokines that inform the adaptive immune system about the nature of the pathogen and instruct naïve T cells to differentiate into the a...
    Author: Lin Sun, Chan…
    Published: 2015/10
    DOI: 10.1016/j.cyto.201…
    PubMed
    The IL-12 family of cytokines in infection, inflammation and autoimmune disorders
    Cytokines are critical coordinators of the immune response necessary for resolving bacterial and viral assaults on the immune system. In particular, the IL-12 family of cytokines are key players in the regulation of T cell responses. These responses are orchestrated by monocytes, macrophages, and de...
    Author: Katrina Gee
    Published: 2009/3
    Keywords: National In…
  4. Nature
    https://www.nature.com › articles

    Interleukin-12 and the regulation of innate resistance and ...

  5. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Interleukin 12: still a promising candidate for tumor ... - PMC

  6. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Immunology of IL-12: An update on functional activities and

  7. People also ask
    What does IL-12 stand for?
    Keywords: cancer immunotherapy; cancer vaccine; cytokine delivery system; interleukin-12 (IL-12); intratumoral administration; localized delivery. Copyright © 2020 Nguyen, Vrabel, Mantooth, Hopkins, Wagner, Gabaldon and Zaharoff.

    Localized Interleukin-12 for Cancer Immunotherapy - PubMed

    pubmed.ncbi.nlm.nih.gov
    Is IL-12 a cytokine?
    Interleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-Îł production in T and NK cells.

    Interleukin-12: Functional activities and implications for disease

    pubmed.ncbi.nlm.nih.gov
    Is IL-12 a heterodimer?
    IL-12 is a heterodimer formed by a 35-kDa light chain (known as p35 or IL-12α) and a 40-kDa heavy chain (known as p40 or IL-12β) 9 (Fig. 2). p35 has homology to other single-chain cytokines, whereas p40 is homologous to the extracellular domain of members of the haematopoietic cytokine-receptor family 15.

    Interleukin-12 and the regulation of innate resistance and adaptive

    nature.com
    Is IL-12 a co-stimulator?
    J. Exp. Med. 180, 223–231 (1994). References 70 and 71 show that in both humans and mice, IL-12 is strongly synergistic with co-stimulatory signals (such as B7–CD28 interactions) for inducing IFN-γ production by and proliferation of both resting and activated T cells, even in the absence of antigen.

    Interleukin-12 and the regulation of innate resistance and adaptive

    nature.com
    Does IL-12 bind to the IL12 receptor?
    IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by IL-12Rβ1 and IL-12Rβ2. [ 6 ] IL-12Rβ2 is considered to play a key role in IL-12 function, since it is found on activated T cells and is stimulated by cytokines that promote Th1 cells development and inhibited by those that promote Th2 cells development.

    Interleukin 12 - Wikipedia

    en.wikipedia.org
    How is IL-12 produced?
    Production of IL-12 is dependent on differential mechanisms of regulation of expression of the genes encoding IL-12, patterns of Toll-like receptor (TLR) expression and cross-regulation between the different DC subsets, involving cytokines such as IL-10 and type I IFN.

    Interleukin-12 and the regulation of innate resistance and adaptive

    nature.com
    Feedback
  8. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    IL-12 Family Cytokines in Cancer and Immunotherapy - PMC

  9. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Localized Interleukin-12 for Cancer Immunotherapy - PubMed

  10. Nature
    https://www.nature.com › articles

    IL-12 and IL-23 cytokines: from discovery to targeted ...

  11. Cell Press
    https://www.cell.com › structure › fulltext

    Structure and assembly of the human IL-12 signaling complex

  13. Results that may be inaccessible to you are currently showing.
    Hide inaccessible results