LINE1 (an abbreviation of Long interspersed nuclear element-1, also known as L1 and LINE-1) is a family of related class I transposable elements in the DNA of many groups of eukaryotes, including animals and plants, classified with the long interspersed nuclear elements (LINEs). [1]

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LINE-1 Retrotransposition-Mediated Deletion Events. In addition to acting as an insertional mutagen, L1-mediated retrotransposition events can lead to various forms of human structural variation.

One of the most prevalent is the Long INterspersed Element-1 (LINE-1, L1) mobile DNA. LINE-1 is rightly receiving increasing interest as a cancer biomarker. Intact LINE-1 elements are self-propagating. They code for RNA and proteins which function to make more copies of …

The 1 Line, formerly Central Link, is a light rail line in Seattle, Washington, United States, and part of Sound Transit's Link light rail system. It serves 23 stations in King and Snohomish counties, traveling 33 miles (53 km) between Lynnwood City Center and Angle Lake stations.

Aug 6, 2020 · Long interspersed nuclear element-1 (LINE-1) retrotransposition is a major hallmark of cancer accompanied by global chromosomal instability, genomic instability, and genetic heterogeneity and has become one indicator for the occurrence, development, and poor prognosis of many diseases.

Jun 7, 2024 · A CRISPR–Cas9 screen identifies genes that modulate long interspersed nuclear element-1 (LINE-1) expression in human cells. LINE-1 5′ UTRs have enhancer features and can activate long-range...

Mar 28, 2013 · LINE-1 (L1) retrotransposons make up a significant portion of human genomes, with an estimated 500,000 copies per genome. Like other retrotransposons, L1 retrotransposons propagate through RNA sequences that are reverse transcribed into DNA sequences, which are integrated into new genomic loci.

LINE-1 is the only remaining active transposon in humans, and it expands by copying and pasting itself to new locations via a process called 'retrotransposition'. To do so, it is first transcribed into RNA – the molecules that help to make proteins – and …

Dec 14, 2023 · The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated nearly one-third of the human genome and serves as an active source of genetic diversity and human disease...