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  1. Wikipedia
    https://en.wikipedia.org › wiki

    Lutetium (177Lu) oxodotreotide - Wikipedia

    • Lutetium ( Lu) oxodotreotide (INN) or Lu dotatate, brand name Lutathera, is a chelated complex of a radioisotope of the element lutetium with dotatate, used in peptide receptor radionuclide therapy. Specifically, it is used in the treatment of cancers which express somatostatin receptors. It is a radiolabeled somatostatin analog. Alternatives to Lu-dotatate include yttriu… See more

    Medical uses

    In the US, Lu dotatate is indicated for the treatment of somatostatin receptor-positive gastroenteropancreatic … See more

    Adverse effects

    The therapeutic effect of Lu derives from the ionizing beta radiation it emits, however this can also be harmful to healthy tissue and organs. The kidneys are particularly at risk as they help to remove Lu dotatate from the bo… See more

    History

    The European Commission approved lutetium ( Lu) oxodotreotide (brand name Lutathera) "for the treatment of unresectable or metastatic, progressive, well differentiated (G1 and G2), somatostati… See more

    Understanding LUTATHERA® (lutetium Lu 177 dotatate)
    Learn about LUTATHERA® (lutetium Lu 177 dotatate) injection for intravenous use, a treatment for adults with GEP-NETs. See full Safety & Prescribing Info.
    LUTATHERA · https://us.lutathera.com/about-lu…
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  1. UChicago Medicine
    https://www.uchicagomedicine.org › ...

    Lutetium-177 PSMA Therapy for Prostate Cancer (Pluvicto)

  2. The New England Journal of Medicine
    https://www.nejm.org › doi › full

    Lutetium-177–PSMA-617 for Metastatic Castration …

    Jun 23, 2021 · Lutetium-177 (177 Lu)–PSMA-617 is a radioligand therapy that delivers beta-particle radiation to PSMA-expressing cells and the surrounding microenvironment.

  3. Mayo Clinic
    https://www.mayoclinic.org › medical-p…

    Lutetium-177 shows significant rPFS benefit for

    Jan 20, 2024 · Metastatic castration-resistant prostate cancer presents treatment challenges, including the side effects of chemotherapy. Mayo Clinic researchers find that lutetium-177 prolongs radiographic progression-free survival in …

  4. ScienceDirect
    https://www.sciencedirect.com › topics › medicine-and-dentistry

    Lutetium 177 - an overview | ScienceDirect Topics

  5. Explore Lu-177

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › books

    Neuroendocrine Tumor Lu-177-Dotatate Therapy

    Feb 12, 2024 · Evaluate the safety and efficacy of 177 Lu-dotatate therapy for treating neuroendocrine tumors in adults. Collaborate with the interprofessional team to educate, treat, and monitor patients with 177 Lu-dotatate-treated …

  7. LUTATHERA
    https://us.lutathera.com › about-lutather…

    Understanding LUTATHERA® (lutetium Lu 177 dotatate)

    Learn about LUTATHERA® (lutetium Lu 177 dotatate) injection for intravenous use, a treatment for adults with GEP-NETs. See full Safety & Prescribing Info.

  8. World Nuclear News
    https://www.world-nuclear-news.org › art…

    Partners mark two years of Lu-177 production at Bruce 7

    3 days ago · In October 2022, Bruce Power became the first commercial nuclear operator to produce lutetium-177 (Lu-177), used in targeted radionuclide therapy to treat cancers like neuroendocrine tumours and prostate cancer, in an …

  9. Food and Drug Administration (.gov)
    https://www.fda.gov › drugs › resources-information...

    FDA approves Pluvicto for metastatic castration-resistant prostate ...

  10. nih.gov
    https://pmc.ncbi.nlm.nih.gov › articles

    Radiolabeled Compounds for Diagnosis and Treatment of Cancer