HER3 activation contributes toward the emergence of ALK
Jan 18, 2022 · Consistent with this, specific siRNA-mediated knockdown of ALK in H2228 and A925L cells increased E-cadherin and phosphorylated HER3 expression and reduced vimentin and ZEB1 expression (Fig. 3b...
STAT3 inhibition suppresses adaptive survival of ALK-rearranged …
Feb 28, 2022 · BCL-XL knockdown using siRNA (si BCL-XL) significantly increased apoptosis induction (Fig. 4d) and decreased viability of ALK -rearranged lung cancer cells, compared to those treated with ...
Selective Therapeutic Targeting of the Anaplastic Lymphoma …
In mice, a nanodelivery system for ALK-specific small interfering RNA (siRNA), based on the conjugation of antibodies directed against the NB-selective marker GD 2 to liposomes, showed strong ALK knockdown in vivo in NB cells, which resulted in cell growth arrest, apoptosis, and prolonged survival.
EML4-ALK-mediated activation of the JAK2-STAT pathway is …
Jun 6, 2021 · To explore the mechanisms involved in the transformation of lung cancer cells triggered by EML4-ALK, we used microarray analysis to generate gene expression profiles for H2228 cells transfected with siRNA-NC or siRNA-EML4-ALK.
The ALK inhibitors, alectinib and ceritinib, induce ALK…
May 1, 2021 · Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that is confirmed only during the embryonic development period in humans. In addition, various ALK gene alterations are known to act as powerful oncogenes and therapeutic targets in …
Emerging Roles of ALK in Immunity and Insights for …
Feb 12, 2020 · Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity.
ALK fusions in the pan-cancer setting: another tumor-agnostic …
Sep 29, 2023 · In this study, 21 patients with various tumor types harboring ALK aberrations (10 patients with ALK gene rearrangement and 11 with ALK mutation or amplifications) were treated with...
Design and evaluation of chemically synthesized siRNA
We designed and evaluated three chemically synthesized small interfering RNAs (siRNAs) for downregulation of the NPM-ALK fusion mRNA.
Selective therapeutic targeting of the anaplastic lymphoma ... - PubMed
In mice, a nanodelivery system for ALK-specific small interfering RNA (siRNA), based on the conjugation of antibodies directed against the NB-selective marker GD (2) to liposomes, showed strong ALK knockdown in vivo in NB cells, which resulted in cell growth arrest, apoptosis, and prolonged survival.
Selective Therapeutic Targeting of the Anaplastic Lymphoma …
Aug 9, 2011 · In mice, a nanodelivery system for ALK-specific small interfering RNA (siRNA), based on the conjugation of antibodies directed against the NB-selective marker GD 2 to liposomes, showed strong ALK knockdown in vivo in NB cells, which resulted in cell growth arrest, apoptosis, and prolonged survival.