p53 signaling in cancer progression and therapy | Cancer Cell ...
WEBDec 24, 2021 · Under physiological conditions, exposure of cells to different stress signals activates the p53 signaling pathway, allowing the cells to activate several transcriptional programs including cell cycle arrest, DNA repair, senescence, and apoptosis leading to suppression of tumor growth .
p53 Pathway for Apoptosis Signaling - Thermo Fisher Scientific
WEBExplore the p53-mediated apoptosis pathway and find antibodies to detect target proteins, including CD178 (Fas Lignad), CD95 (APO-1/Fas), p53, and Caspase-9.
Apoptosis - the p53 network - The Company of Biologists
WEBOct 15, 2003 · Deconstruction of p53-mediated apoptosis reveals an extensive network of signaling pathways triggered by p53 to ensure an appropriate response to a given stress.
WEBP53 induces apoptosis in nontransformed cells mostly by direct transcriptional activation of the pro-apoptotic BH3-only proteins PUMA and (to a lesser extent) NOXA.
Exploring the multiple roles of guardian of the genome: P53
WEBP53 can induce apoptosis in a genetically unstable cell by interacting with many pro-apoptotic and anti-apoptotic factors. Furthermore, P53 can activate autophagy, which also plays a role in tumour suppression. P53 also regulates many metabolic pathways of glucose, lipid, and amino acid metabolism.
The Fundamental Role of the p53 Pathway in Tumor Metabolism …
WEBMar 14, 2012 · The tumor suppressor p53 is one of the most highly studied in the field of cancer research because of its role in tumor cell survival and apoptosis. However, tumor metabolic reprogramming fuels cancer cell malignant growth and proliferation. In this review, we systematically document the mechanisms of p53 in tumor metabolism …
P53, Cell Cycle Arrest and Apoptosis | SpringerLink
WEBThe tumor suppressor protein p53 acts as a major node in a complex signaling pathway that evolved to sense a broad range of cellular stresses such as DNA damage, oncogene activation, nucleotide depletion, and hypoxia (Figure 1).
WEBPUMA expression inhibits cell growth and rapidly induces apoptosis through a pathway involving cytochrome c release and activation of caspase 3 and 9.34,35 p53AIP1 (for p53-regulated...
WEBp53 is an efficient inhibitor of cell growth and causes cell cycle arrest and apoptosis (Figure 1). Regulation of p53 activity is therefore critical to allow both normal cell growth and tumor suppression. The basal activity of p53 remains low in normal or un-stressed cells due to its rapid turnover. Multiple
Cancers | Free Full-Text | Role of p53 in Cell Death and Human
WEBMar 3, 2011 · Indeed, mutant p53 has an oncogenic potential. In some cases, malignant cancer cells bearing p53 mutations display a chemo-resistant phenotype. In response to a variety of cellular stresses such as DNA damage, p53 is induced to accumulate in cell nucleus to exert its pro-apoptotic function.
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