P14arf - an overview | ScienceDirect Topics
p14ARF is a tumor suppressor gene located within the INK4bARF-INK4a locus of 9p21 chromosome. This gene encodes the corresponding 14 kDa p14ARF protein, which is predominantly localized in the nucleolus.
P14ARF: The Absence that Makes the Difference - PMC - PubMed …
P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis.
p14ARF forms meso-scale assemblies upon phase separation with …
3 days ago · Here we show that p14ARF assembles into a gel-like meso-scale network upon phase separation with NPM1. This assembly is mediated by intermolecular contacts formed by hydrophobic residues in an α ...
p14ARF interacts with the focal adhesion kinase and protects
Apr 24, 2017 · Our data uncover a novel function for p14ARF in protecting cells from anoikis that may reflect its role in anchorage independence, a hallmark of malignant tumor cells.
p14ARF links the tumour suppressors RB and p53 | Nature
Sep 10, 1998 · Here we show that E2F-1 directly activates expression of the human tumour-suppressor protein p14ARF (the mouse homologue is called p19ARF), which binds to the MDM2-p53 complex and prevents p53 ...
P14ARF: The Absence that Makes the Difference - PubMed
Jul 20, 2020 · P14 ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14 ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis. P14 ARF functions can be played through interactions with several proteins.
P14ARF: The Absence that Makes the Difference - MDPI
Jul 20, 2020 · P14ARF is a tumor suppressor encoded by the CDKN2a locus that is frequently inactivated in human tumors. P14ARF protein quenches oncogene stimuli by inhibiting cell cycle progression and inducing apoptosis.
Clinicopathological significance of p14ARF expression in lung …
May 8, 2017 · p14 ARF, a tumor suppressor protein, encoded by the p16 tumor suppressor gene, has been reported to be associated with the clinicopathological features of lung cancer. However, the evaluated outcomes were inconsistent and remained inconclusive.
The p14ARF tumor suppressor restrains androgen receptor activity …
Jul 7, 2020 · The best studied function of p14ARF is its interaction with and inhibition of two ubiquitin ligases, MDM2 and ARF-BP1/Mule, which target p53 for degradation [10, 11] thus potentiating p53 activity . p14ARF can interact with other proteins including B23, p63, p32, Miz1, p16INK4a, E2F and TBP-1 .
The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in …
As major markers for aging and senescence, p16INK4, p14ARF/p19ARF, and p21 are established. Importantly, senescence is also implicated in development, cancer, and tissue homeostasis. While many markers of senescence have been identified, none are able to unambiguously identify all senescent cells.
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