microRNAs in action: biogenesis, function and regulation
WEBJun 28, 2023 · Although core features of miRNA biogenesis and function were revealed early on, recent years continue to uncover fundamental information on the structural and molecular dynamics of core miRNA...
Overview of MicroRNA Biogenesis, Mechanisms of Actions, …
WEBAug 3, 2018 · In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. We also summarize the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs.
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and ... - PubMed
WEBAug 3, 2018 · In this review, we provide an update on canonical and non-canonical miRNA biogenesis pathways and various mechanisms underlying miRNA-mediated gene regulations. We also summarize the current knowledge of the dynamics of miRNA action and of the secretion, transfer, and uptake of extracellular miRNAs.
Regulation of microRNA biogenesis - Nature Reviews Molecular …
WEBJul 16, 2014 · Key Points. MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Biogenesis of miRNA is under tight temporal and spatial control. Dysregulation of...
A Structural View of miRNA Biogenesis and Function
WEBJan 18, 2022 · In this review, we summarize the application of structural biology for the characterization of the molecular players involved in miRNA biogenesis (processors and effectors), starting from the X-ray crystallography methods to the more recent cryo-electron microscopy protocols.
microRNAs in action: biogenesis, function and regulation
WEBMany of these latest insights were enabled by recent technological advances, including massively parallel assays, cryogenic electron microscopy, single-molecule imaging and CRISPR-Cas9 screening. Here, we summarize the current understanding of miRNA biogenesis, function and regulation, and outline challenges to address in the future.
Regulation of microRNA biogenesis and its crosstalk with other
WEBSep 18, 2018 · Transcription of miRNAs, their processing by Drosha and Dicer and RISC loading are key steps in miRNA biogenesis, and various additional factors facilitate, support or inhibit these processes.
The Fundamentals of miRNA Biology: Structure, Biogenesis, and ...
WEBMar 17, 2020 · The origins of cellular miRNAs, their biogenesis, functions, and regulation of their activity are discussed. The publication is aimed at readers looking for first insights into the intricacies of miRNA biology, but can also serve as a source of reference material for specialists in the area.
miRNA Biogenesis and Regulation of Diseases: An Updated …
WEBNov 29, 2022 · This chapter summarizes miRNA biogenesis and explores their potential roles in a variety of diseases. miRNAs hold huge potential for diagnostic and prognostic biomarkers and as predictors of drug response.
MicroRNA: Biogenesis, Function and Role in Cancer - PMC
WEBMicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form mature microRNA.