【耀文解读】深度解析mRNA序列元件：Cap, CDS, UTR, polyA
有研究显示，在快速增殖的细胞中，mRNA展现出较短的3′UTR序列，这一变化能够减少miRNA结合位点，促使蛋白表达提高。 此外，通过减少3′UTR序列内的非结构化序列可促进poly（A）尾与翻译元件的结合，提高蛋白翻译效率。
Three prime untranslated region - Wikipedia
In molecular genetics, the three prime untranslated region (3′-UTR) is the section of messenger RNA (mRNA) that immediately follows the translation termination codon. The 3′-UTR often contains regulatory regions that post-transcriptionally influence gene expression .
一文教会你查找基因的启动子、UTR、TSS等区域以及预测转录因 …
Jun 3, 2019 · UTR（Untranslated Regions)： 即非翻译区，是信使RNA（mRNA）分子两端的非编码片段。. 5'-UTR 从mRNA起点的甲基化鸟嘌呤核苷酸帽延伸至AUG起始密码子， 3'-UTR 从编码区末端的终止密码子延伸至多聚A尾巴（Poly-A）的末端。. 1查找基因的启动子区域-NCBI. 1.
What Are 3' UTRs Doing? - PubMed
Oct 1, 2019 · 3' untranslated regions (3' UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. In addition, 3' UTRs can establish 3' UTR-mediated protein-protein interactions (PPIs), and thus can transmit genetic information e ….
3'UTR是做什么的？|mRNA|UTR|异构体|蛋白质|元件|序列|基因|-健 …
Oct 27, 2020 · 3. 3'utr调控mrna的定位. 在发现3'utr的同时，研究人员也发现了3'utr是mrna亚细胞定位的重要调节因子。早期关于mrna定位的研究，主要集中在卵或者卵母细胞当中，但是mrna的定位不仅在发育早期至关重要，在其他的细胞(成纤维细胞，神经元等)都具有很重要的作用。
3′ Untranslated Regions Are Modular Entities That Determine ...
Protein-coding sequences increase mRNA stability of most genes but do not affect the relative stability of 3′ isoforms within a 3′ UTR. Pairwise comparisons of WT versus ΔORF loci not only show that 3′ UTRs determine poly(A) profiles, but they also provide information on the effect of protein-coding sequences on steady-state mRNA levels.
Widespread 3′UTR capped RNAs derive from G-rich regions in …
Nov 7, 2024 · The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a method for the detection of capped 5′ ends of mRNAs, additionally reveals a large number of apparently 5′ capped RNAs derived from locations within the body of the transcript, including …
What Are 3′ UTRs Doing? - CSHL P
SUMMARY. 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and translation. In addition, 3′ UTRs can establish 3′ UTR-mediated protein–protein interactions (PPIs), and thus can transmit genetic information encoded in 3′ UTRs to ...
Quantifying 3′UTR length from scRNA-seq data reveals changes
May 14, 2024 · In mRNAs, the 3′ untranslated region (3′UTR) is located between the coding sequence stop codon and the poly(A) tail. mRNA and 3′UTR length is determined by pre-mRNA cleavage and ...
eIF3 engages with 3’-UTR termini of highly translated mRNAs - eLife
6 days ago · In neurons, 3’-UTR isoforms are known to play key roles in mRNA localization and expression in different neuronal compartments (Taliaferro et al., 2016; Tushev et al., 2018) and alternative polyadenylation is highly prevalent in the nervous system, leading to the expression of multiple mRNA isoforms with different 3’-UTR lengths (Miura et ...