- Adult zebrafish have an innate ability to recover from severe spinal cord injury. Here, we report a comprehensive single nuclear RNA sequencing atlas that spans 6 weeks of regeneration. We identify cooperative roles for adult neurogenesis and neuronal plasticity during spinal cord repair.www.biorxiv.org/content/10.1101/2023.05.19.541505v3
Identification of key genes involved in recovery from spinal cord ...
The RNA sequencing dataset GSE77025 (Mokalled et al., 2016) was used to investigate gene-expression changes in the adult zebrafish spinal cord 2 weeks after complete transection. The dataset included two sham-injured spinal cord samples and two SCI samples.
See results only from pmc.ncbi.nlm.nih.govGEO Accession viewer - Nati…
The goals of this study is to compare transcriptome profiles (RNA-seq) of …
RNA sequencing screening o…
RNA sequencing technology can screen differentially expressed genes at …
Temporal single-cell transcri…
To identify the developmental origins and transcriptional profiles of motor neurons …
Single-cell analysis of innate …
Adult zebrafish have an innate ability to recover from severe spinal cord injury. …
A unique macrophage subpo…
Using single-cell RNA-seq of progenitor cells and macrophages, as well as cell …
Single-cell analysis of innate spinal cord regeneration ... - Nature
Aug 15, 2024 · Adult zebrafish have an innate ability to recover from severe spinal cord injury. Here, we report a comprehensive single nuclear RNA sequencing atlas that spans 6 weeks of …
Spinal cord repair is modulated by the neurogenic factor Hb
Aug 11, 2023 · Here, we find that ependymal cells in zebrafish spinal cords produce the neurogenic factor Hb-egfa upon transection injury. Animals with hb-egfa mutations display …
GEO Accession viewer - National Center for Biotechnology …
Nov 8, 2021 · The goals of this study is to compare transcriptome profiles (RNA-seq) of zebrafish spinal cord before and after injury. The five segments rostral and five segments caudal to the …
RNA sequencing screening of differentially expressed genes after …
Dec 5, 2018 · RNA sequencing technology can screen differentially expressed genes at different time points after spinal cord injury. Through analysis and verification, genes strongly …
- Author: Yi Li, Ying Chen, Xiang Li, Jian Wu, Jing-Ying Pan, Ri-Xin Cai, Ri-Yun Yang, Xiao-Dong Wang
- DOI: 10.4103/1673-5374.255994
- Publish Year: 2019
- Publication: Neural Regen Res. 2019 Sep; 14(9): 1583-1593.
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Temporal single-cell transcriptomes of zebrafish spinal cord pMN ...
To identify the developmental origins and transcriptional profiles of motor neurons and OPCs, we performed single-cell RNA sequencing on isolated pMN cells from embryonic zebrafish trunk …
Zebrafish Spinal Cord Regeneration Atlas - shinypath.wustl.edu
Apr 17, 2024 · Welcome to the Single Nuclei Atlas of Zebrafish Spinal Cord (SC) Regeneration. To achieve a comprehensive understanding of the pro-regenerative cell identities that direct …
An injury-induced serotonergic neuron subpopulation ... - Nature
Dec 7, 2021 · Spinal cord injury (SCI) interrupts long-projecting descending spinal neurons and disrupts the spinal central pattern generator (CPG) that controls locomotion. The intrinsic …
Single-cell analysis of innate spinal cord regeneration identifies ...
Dec 8, 2023 · Adult zebrafish have an innate ability to recover from severe spinal cord injury. Here, we report a comprehensive single nuclear RNA sequencing atlas that spans 6 weeks of …
A unique macrophage subpopulation signals directly to ... - PubMed
Jun 7, 2021 · Using single-cell RNA-seq of progenitor cells and macrophages, as well as cell-type-specific manipulations, we provide evidence for a direct signaling axis from specific lesion …
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