In the areas with a high prevalence of the use of xylazine mixed with fentanyl or heroin, abscesses, and painful skin ulcers are very often reported. The mechanism is thought to be due to its direct vasoconstricting effect on local blood vessels and the resultant decreased skin perfusion.

Apr 11, 2023 · Important clinical differentials in xylazine-induced cutaneous ulcerations in PWID include levamisole-, cocaine-, and pentazocine-induced skin ulcers (Table I) 5; necrotizing fasciitis; pyoderma gangrenosum and vasculitic ulcers; acute limb ischemia; and embolia cutis medicamentosa.

Jan 12, 2024 · When an individual with a xylazine-associated wound has signs or symptoms that indicate possible complications, such as exposed bone or tendon or signs of local or systemic infection, they should be referred to a provider with appropriate clinical training.

With the infiltration of xylazine into the drug supply, xylazine-associated wounds (colloquially called “tranq wounds”) have become recognized as a distinct clinical entity. Experts theorize that the peripheral vasoconstrictive properties of xylazine lead to poor perfusion and necrosis.

Mar 3, 2025 · Xylazine sores are severe skin ulcers and necrotic wounds that develop as a result of xylazine use. Unlike typical injection site infections, these sores can appear on various parts of the body, even in users who do not inject the drug.

Jul 24, 2024 · Xylazine or “tranq” wounds – characterized by deep pockets of dead tissue – have become increasingly visible in Philadelphia among people who use drugs.

Jan 6, 2023 · Xylazine, a clonidine analogue, may also cause ulcers through vasoconstriction and necrosis. Skin ulcers related to IDU may be superficially infected and may be associated with SSTIs, osteomyelitis, bacteremia, or endocarditis.

Aug 13, 2023 · Some come in with arms ballooned two or three times their size due to infection or with sores that fester and turn black. Not all the wounds are caused by xylazine, but the drug is increasing...

Wash the wounds daily with plain soap and warm water, pat dry with clean cloth, and cover lightly with petroleum jelly before bandaging. Clean hands with soap and water before touching wounds or wear sterile gloves. Gently wash wounds with soap and water, or with saline (water and salt). Put ointment on a bandage, then place on wound.

Feb 13, 2023 · Two new substances associated with illicit opioid use have been spreading in the United States and Canada, contributing to opioid use complications and overdoses. “Frankenstein opioids,” or...