XBP1 - Wikipedia
X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. [5] [6] The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. [7]
XBP1 Gene - GeneCards | XBP1 Protein | XBP1 Antibody
Oct 2, 2024 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.
X-box binding protein 1 (XBP1) function in diseases - PubMed
As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease progression and prognosis.
Cell子刊：王立堃团队发现抑制XBP1/胆固醇信号，可提高癌症免 …
这提示，肿瘤细胞中的IRE1α/XBP1信号可能通过调节肿瘤免疫促进了肿瘤的生长。研究者进一步利用质谱流式技术分析发现，肿瘤细胞内XBP1的缺失减少了肿瘤微环境中髓系来源的免疫抑制性细胞（myeloid-derived suppressor cell，MDSC），增加了活化的CD8 T细胞。
XBP1 modulates endoplasmic reticulum and mitochondria …
Feb 17, 2023 · XBP1 deficiency reduced tissue damage and cell apoptosis, protecting the mitochondria. Disruption of XBP1 was associated with reduced NLRP3 and cleaved caspase-1 levels and markedly improved...
XBP-1 and the unfolded protein response (UPR) - Nature
Jul 2, 2020 · XBP1 transcripts are rapidly upregulated in B cells in vitro by stimuli that induce plasma cell differentiation and are found at high levels in both normal plasma cells and plasma cells from the...
Roles of XBP1s in Transcriptional Regulation of Target Genes
Jul 8, 2021 · The spliced form of X-box binding protein 1 (XBP1s) is an active transcription factor that plays a vital role in the unfolded protein response (UPR). Under endoplasmic reticulum (ER) stress, unspliced Xbp1 mRNA is cleaved by the activated stress sensor IRE1α and converted to the mature form encoding spliced XBP1 (XBP1s).
Emerging Roles for XBP1, a sUPeR Transcription Factor - PMC
X-box binding protein 1 (XBP1) is a unique basic region leucine zipper (bZIP) transcription factor whose active form is generated by a nonconventional splicing reaction upon disruption of homeostasis in the endoplasmic reticulum (ER) and activation ...
X-box binding protein 1 (XBP1) function in diseases - Wiley Online …
Dec 16, 2020 · As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease progression and prognosis.
XBP1 X-box binding protein 1 [ (human)] - National Center for ...
The unfolded protein response (UPR)-activated transcription factor X-box-binding protein 1 (XBP1) induces microRNA-346 expression that targets the human antigen peptide transporter 1 (TAP1) mRNA and governs immune regulatory genes.