Protein Wnt-5a - Wikipedia
WEBIt encodes a protein showing 98%, 98%, and 87% amino acid identity to the mouse, rat and the xenopus Wnt5a protein, respectively. Wnts, specifically Wnt5a, have also been positively correlated and implicated in inflammatory diseases such as rheumatoid arthritis, tuberculosis, and atherosclerosis.
Wnt5a: its signalling, functions and implication in diseases
WEBWnt5a is a representative ligand that activates the β-catenin-independent pathways. Because the β-catenin-independent pathway includes multiple signalling cascades in addition to the planar cell polarity and Ca(2+) pathway, Wnt5a regulates a variety of cellular functions, such as proliferation, diff …
WNT5A Gene - GeneCards | WNT5A Protein | WNT5A Antibody
WEBAug 6, 2024 · WNT5A (Wnt Family Member 5A) is a Protein Coding gene. Diseases associated with WNT5A include Robinow Syndrome, Autosomal Dominant 1 and Autosomal Dominant Robinow Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and ncRNAs involved in Wnt signaling …
WNT-5A: signaling and functions in health and disease
WEBOct 29, 2015 · WNT-5A predominantly activates β-catenin-independent WNT signaling cascade but can also activate β-catenin signaling to relay its diverse cellular effects such as cell polarity, migration, proliferation, cell survival, and immunomodulation.
Wnt5a is a TLR2/4-ligand that induces tolerance in human
WEBMay 9, 2019 · Wnt5a is a signalling protein mainly involved in developmental processes and cancer. The effect of Wnt5a on inflammatory myeloid cells is controversial. Here, we combine primary cell cultures,...
Wnt5a: A promising therapeutic target for inflammation, …
WEBDec 1, 2023 · Wnt5a is a highly evolutionarily conserved non-canonical Wnt ligand on chromosome 3p14-p21 and contains multiple polyadenylation sites. Wnt5a can activate both canonical and non-canonical signaling pathways, and different signaling pathways lead to Wnt5a playing different roles in different diseases [7], [8].
WNT5A gene - MedlinePlus
WEBThe protein produced from the WNT5A gene is part of chemical signaling pathways that control the movement of cells (cell migration) and attachment of cells to one another (cell adhesion) during early development.
WNT5A Wnt family member 5A [ (human)] - National Center for ...
WEBOver-expression of Wnt5a in transgenic mice disrupts epithelial-response to FGF10 and regulates Shh signaling. Altered mRNA expression is associated with prostate cancer recurrence. The WNT gene family consists of structurally related genes which encode secreted signaling proteins.
Wnt signaling in lung development, regeneration, and disease ...
WEBMay 20, 2021 · Furthermore, epithelial Wnt5a regulates distal lung morphogenesis via suppression and activation of sonic hedgehog (Shh) and Fgf10 signaling, respectively 34.
Wnt5a is a crucial regulator of neurogenesis during cerebellum …
WEBFeb 16, 2017 · We demonstrate that loss of Wnt5a results in cerebellar hypoplasia and depletion of GABAergic and glutamatergic neurons.