Vinca alkaloid - Wikipedia
Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus (basionym Vinca rosea) and other vinca plants. They block beta-tubulin polymerization in a dividing cell.
Vinca Alkaloid Toxicity - StatPearls - NCBI Bookshelf
Mar 10, 2024 · Identify the signs and symptoms of vinca alkaloid toxicity in patients, including but not limited to neurotoxicity, gastrointestinal effects, and hematological abnormalities. Differentiate between vinca alkaloid toxicity and other causes of toxicity to ensure timely intervention.
Vinca Alkaloid - an overview | ScienceDirect Topics
Vinca alkaloids (Vas) are the phytochemicals that are naturally found in Catharanthus roseus and the well-known anticancer compounds include vinorelbine, vindesine, vincristine, and vinblastine. Currently around 64 varieties of C. roseus are screened for phytochemicals.
Vinca alkaloids as a potential cancer therapeutics: recent
May 24, 2023 · Vinca alkaloids (vincristine and vinblastine), as well as semisynthetic derivatives (vinorelbine, vindesine, and vinflunine), are potent antimitotic chemotherapeutics used to treat hematological and lymphatic neoplasms (Galindo-Solís and Fernández 2022).
Vinca alkaloids - PubMed
There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS). VCR, VBL and VRL have been approved for use in the United States.
The Vinca Alkaloids - Holland-Frei Cancer Medicine - NCBI …
The Vinca alkaloids have been widely incorporated into combination chemotherapy regimens for palliative and curative therapies, based not only on their lack of cross-resistance with drugs that alkylate DNA, but also on their distinct mechanism of action.
Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids
Vinca alkaloids are anticarcinogenic agents that act by binding to intracellular tubulin, which is used in many chemotherapeutic regimens for a wide variety of cancers. The alkaloids inhibit cell division by blocking mitosis, and also inhibit purine and …
Vinca alkaloids and analogues as anti-cancer agents: Looking …
Sep 15, 2018 · Vinca alkaloids (VAs) are the earliest developed MTAs and approved for clinical use (Vincristine, Vinblastine, Vinorelbine, Vindesine, and Vinflunine) as agents in the treatment of hematological and lymphatic neoplasms.
Vinca Alkaloid - an overview | ScienceDirect Topics
Vinca alkaloids are a class of medications derived from the pink periwinkle plant. These alkaloids cause cell death by interfering with microtubules, which are involved in various cellular activities. Vinca alkaloids are commonly used in combination with chemotherapy to …
Vinca Alkaloid - an overview | ScienceDirect Topics
Vinca alkaloids are cell cycle-specific agents that block mitosis with metaphase arrest by binding to tubulin, which is a critical component of microtubules. Vinca alkaloids disrupt the mitotic apparatus after binding to tubulin, resulting in mitotic arrest in metaphase.
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