Vascular endothelial growth factor (VEGF)/ vascular endothelial growth factor receptor (VEGFR) inhibitors are agents that inhibit the activity of VEGF and VEGFR. VEGR and VEGFR (a …

Oct 11, 2024 · Anti-VEGF drugs (also called VEGF inhibitors) slow the abnormal growth of blood vessels associated with certain cancers and degenerative eye conditions, such as age-related …

It can activate both the NF-κB and MAPK signalling pathways, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell …

Dec 26, 2017 · The VEGF (vascular endothelial growth factor) pathway has emerged as an important target for cancer therapy, with VEGF signaling pathway (VSP) inhibitors having been …

Vascular endothelial growth factor receptors (VEGFRs) are a family of receptor protein tyrosine kinases that play an important role in the regulation of tumor-induced angiogenesis. Currently, …

Anti-vascular endothelial growth factor tyrosine kinase inhibitors result in increased vasoconstrictor levels, decreased vasodilator levels, vascular rarefaction, and renal damage, …

In this review, we summarize anti-VEGFA peptides identified so far and discuss the molecular basis of their inhibitory activity to highlight their pharmacological potential as anti-angiogenic …

Apr 15, 2019 · In this review, after briefly summarizing the anticancer effects, we discuss the mechanisms that potentially underlie the unwanted effects of VEGF inhibitors, focusing on ET …

Dec 27, 2012 · The recent launch onto the market of five VEGFR inhibitors indicates the therapeutic value of these agents and the importance of the research in the field of …

Feb 6, 2019 · In this review, after briefly summarizing the anticancer effects, we discuss the mechanisms that potentially underlie the unwanted effects of VEGF inhibitors, focusing on ET …