VKORC1 - Wikipedia
WEBThe VKORC1 protein is a key enzyme in the vitamin K cycle. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues.
VKORC1 gene - MedlinePlus
WEBThe VKORC1 gene provides instructions for making a vitamin K epoxide reductase enzyme. The VKORC1 enzyme is made primarily in the liver. It spans the membrane of a cellular structure called the endoplasmic reticulum, which is …
VKORC1 Gene - GeneCards | VKOR1 Protein | VKOR1 Antibody
WEBAug 6, 2024 · GeneCards Summary for VKORC1 Gene. VKORC1 (Vitamin K Epoxide Reductase Complex Subunit 1) is a Protein Coding gene. Diseases associated with VKORC1 include Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2 and Coumarin Resistance.
Warfarin Therapy and VKORC1 and CYP Genotype - Medical …
WEBMar 8, 2012 · The VKORC1 gene encodes the vitamin K epoxide reductase enzyme, which catalyzes the rate-limiting step in vitamin K recycling (converting vitamin K epoxide to vitamin K). This enzyme is also the drug target for warfarin.
VKORC1 vitamin K epoxide reductase complex subunit 1
WEBAug 27, 2024 · This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane.
VKORC1 Pharmacogenomics Summary - PMC - National Center …
WEBThe VKORC1 gene encodes the VKORC1 (vitamin K epoxide reductase) protein, which is a key enzyme in the vitamin K cycle [1,2]. VKORC1 is a 163 amino acid integral membrane protein associated with the endoplasmic reticulum and VKORC1 mRNA is broadly expressed in many different tissues .
Mutations in VKORC1 cause warfarin resistance and multiple
WEBFeb 5, 2004 · Overexpression of wild-type VKORC1, but not VKORC1 carrying the VKCFD2 mutation, leads to a marked increase in VKOR activity, which is sensitive to warfarin inhibition.
VKORC1 and the vitamin K cycle - PubMed
WEBGenetic studies have shown that the VKORC1 gene extends over 5126 base pairs on human chromosome 16 and comprises three exons. Mutations in the VKORC1 gene causes generalized defective vitamin K-dependent clotting factors (VKCFD2) and warfarin resistance (WR).
VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1; VKORC1 …
WEBDec 17, 2021 · The VKORC1 gene encodes vitamin K epoxide reductase complex subunit-1, a small transmembrane protein of the endoplasmic reticulum, which plays a major role in the vitamin K pathway and is the target protein of …
Vitamin K epoxide reductase complex subunit 1 (VKORC1): A ...
WEBMay 30, 2017 · VKORC1 γ-carboxylates vitamin K-dependent proteins. Its polymorphism guides personalized warfarin dosing. VKORC1 SNPs determination could help identify the uLM-CRC pts who best benefit from intensive HAI therapy.