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  1. The human Vδ2 + T-cell compartment comprises …

    • Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we show that the Vδ2+ c… See more

    Introduction

    γδ T cells have coevolved alongside B cells and αβ T cells in the vertebrate immune system for almost 450 million years1. They provide anti-microbial2 and anti-tumour immunity3, … See more

    Nature
    Results

    Adult and neonatal Vδ2+ T cells have similar TCR diversity
    Consistent with previous studies, we confirmed that human cord blood Vδ2+ γδ T cells wer… See more

    Nature
    Discussion

    This study sheds light on the biology of Vδ2+ T cells, highlighting divergent Vγ9+ and Vγ9− subsets. Despite the ~ten-fold increase in Vγ9+ Vδ2+ T-cell numbers in the first yea… See more

    Nature
    Methods

    Ethical approval and samples
    Peripheral blood samples were obtained from healthy donors who had provided written informed consent for sample collection a… See more

    Nature
    Acknowledgements

    We thank all donors and patients who participated in this study, clinical staff at UHB NHS Foundation Trust for recruitment and provision of liver samples, the AMC biobank sta… See more

    Nature
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  1. Studies of V Gamma
  2. Application of the V-Gamma map to vehicle breakup analysis

  3. Lorentz factor - Wikipedia

  4. Self-activation of Vγ9Vδ2 T cells by exogenous ...

  5. Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising …

  6. Differentiation, phenotype, and function of interleukin …

    Jul 7, 2011 · Here we report that coculture of naive Vγ9Vδ2 T cells with phosphoantigens and a cocktail of cytokines (IL-1-β, TGF-β, IL-6, and IL-23), leads to selective expression of the transcription factor RORγt and polarization …

  7. Human Vγ9Vδ2 T cells: From signals to functions - ScienceDirect

  8. V gamma gene usage in peripheral blood gamma delta T cells

  9. Improving the Efficiency of Vγ9Vδ2 T-Cell …

    Apr 18, 2018 · Tumor growth is inhibited via different mechanisms including the release of pro-inflammatory cytokines, granzymes and perforin, and the engagement of apoptosis inducing receptors (69). Several drugs and …

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