Common side effects

• Urine discoloration
• Abdominal pain with cramps
• Nausea and vomiting
• Diarrhea
• Increased urinary frequency

If any of these effects persist or worsen, tell your doctor or pharmacist promptly

• Nausea
• Vomiting
• Dry mouth
• Dizziness
• Drowsiness
• Blurred vision
• Constipation

Tell your doctor right away if you have any serious side effects, including

• Hot/dry/flushed skin
• Decreased sweating
• Eye pain
• Difficult urination
• Signs of kidney problems

Get medical help right away if you have any very serious side effects, including

• Easy bruising/bleeding
• Black/tarry stools
• Stomach/abdominal pain
• Vomit that looks like coffee grounds
• Signs of liver problems

This drug may rarely cause an attack of extremely high blood pressure , which may be fatal. Many drug interactions can increase this risk . Get medical help right away if any of these serious side effects occur

• Severe headache
• Fast/slow/irregular/pounding heartbeat
• Chest pain
• Neck stiffness/soreness
• Severe nausea/vomiting
• Sweaty/clammy skin
• Widened pupils
• Vision changes
• Sudden sensitivity to light

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take . Get medical help right away if you develop some of the following symptoms

• Fast heartbeat
• Hallucinations
• Loss of coordination
• Severe dizziness
• Severe nausea/vomiting/diarrhea
• Twitching muscles
• Unexplained fever
• Unusual agitation/restlessness

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including

• Rash
• Itching/swelling
• Severe dizziness
• Trouble breathing

Other things to note

• To relieve dry mouth, suck on hard candy or ice chips, chew gum, drink water, or use a saliva substitute.
• This medication causes urine and sometimes stools to turn blue-green. This effect is harmless and will disappear when the medication is stopped.

Before taking this medication, tell your doctor if you've had:

• Kidney problems
• Liver problems
• Urinary blockage problems
• Difficulty urinating (such as due to an enlarged prostate)
• Stomach/intestinal disorders (such as obstruction, ulcers)
• Glaucoma (narrow angle type)
• Heart problems (such as coronary heart disease, congestive heart failure, fast/irregular heartbeat)
• High blood pressure
• Myasthenia gravis
• Bleeding/clotting problems
• Certain enzyme deficiencies (pyruvate kinase or G6PD deficiency)
• Aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs)
• Growths in the nose (nasal polyps)
• Stroke
• Severe/frequent headaches
• A certain kind of adrenal gland tumor (pheochromocytoma)
• Dehydration

Products that may interact with this drug include:

• Apraclonidine
• Atomoxetine
• Bupropion
• Buspirone
• Carbamazepine
• Cyclobenzaprine
• Dextromethorphan
• Maprotiline
• Methotrexate
• Mifepristone
• Potassium capsules/tablets
• Pramlintide
• Tetrabenazine
• Some narcotic drugs (such as fentanyl, meperidine, methadone, tapentadol)
• Certain Parkinson's disease drugs (entacapone, levodopa, tolcapone)
• Certain high blood pressure drugs (guanethidine, methyldopa)
• Sulfonamide drugs (including sulfa antibiotics such as sulfamethoxazole)
• Sympathomimetics (such as amphetamine, ephedrine)
• Tricyclic antidepressants (such as amitriptyline/nortriptyline)
• Products that decrease the amount of acid in the urine (such as antacids, sodium bicarbonate, potassium/sodium citrate, acetazolamide)

• Not recommended during pregnancy.
• May make you drowsy or dizzy. Drive with caution
• Swallow with 8 oz water. Do not lie down for 10min
• Limit alcohol and avoid aspirin-like pain drugs.
• Inform doctor about all the medicines you use
• May cause harmless green- blue urine and stools.
• Call doctor if chest pain or severe headache occur
• Avoid tyramine-rich food (e.g., aged cheese).

This medication is used to relieve the discomfort, pain, frequent urge to urinate, and cramps/spasms of the urinary tract caused by an infection or a medical procedure.

Status: Discontinued

Alternate Brand Names: Hyophen · Phosphasal · Urelle · Uribel

Drug Class: Misc Anti-Infective Combinations · Urinary Anti-infective Methenamine-Antispas-Analg Combinations

Availability: Prescription Required

Pregnancy: Consult a doctor before using

Lactation: This drug should not be given to breastfeeding mothers

Alcohol: Limit intake while taking this medication

Driving: May cause drowsiness or dizziness. Use caution