UCP2 - Wikipedia
WEBMitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene. [5] Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane …
UCP2 Gene - GeneCards | UCP2 Protein | UCP2 Antibody
WEBAug 6, 2024 · UCP2 (Uncoupling Protein 2) is a Protein Coding gene. Diseases associated with UCP2 include Body Mass Index Quantitative Trait Locus 4 and Hyperinsulinism Due To Ucp2 Deficiency.
An interplay between UCP2 and ROS protects cells from high
WEBOct 8, 2021 · The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular disease of both animal models and humans. UCP2 downregulation upon high-salt feeding favors...
UCP2, a mitochondrial protein regulated at multiple levels
WEBIn this review, we describe novel findings concerning events that can occur in a concerted manner at various levels: Ucp2 gene mutation (single nucleotide polymorphisms), UCP2 mRNA and protein expression (transcriptional, translational, and protein turn-over regulation), UCP2 proton conductance (ligands and post-transcriptional modifications ...
Uncoupling Protein 2 as a Pathogenic Determinant and …
WEBMar 3, 2022 · Uncoupling protein 2 (UCP2) is a mitochondrial protein that acts as an anion carrier. It is involved in the regulation of several processes, including mitochondrial membrane potential, generation of reactive oxygen species within the inner mitochondrial membrane and calcium homeostasis.
Uncoupling Protein 2: A Key Player and a Potential Therapeutic …
WEBOct 15, 2017 · Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative stress accumulation.
Uncoupling Protein 2 in Cardiovascular Health and Disease
WEBAug 2, 2018 · Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. It uncouples oxygen consumption from ATP synthesis. UCP2 is ubiquitously expressed in most cell types to reduce oxidative stress. It is tightly regulated at the transcriptional, translational, and post-translational levels.
Uncoupling Protein 2: A Key Player and a ... - Wiley Online Library
WEBOct 15, 2017 · Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative stress accumulation.
UCP2, a Member of the Mitochondrial Uncoupling Proteins: An
WEBJun 13, 2024 · UCP2 is an uncoupling protein homolog to UCP1. Unlike UCP1, which participates in non-shivering thermogenesis by uncoupling oxidative phosphorylation (OXPHOS), UCP2 does not perform a canonical H + leak, consuming the protonmotive force (Δ p) through the inner mitochondrial membrane. The UCP2 biological role is elusive.
Endothelial UCP2 Is a Mechanosensitive Suppressor of …
WEBJul 28, 2022 · UCP2 (Uncoupling protein 2), a key mitochondrial antioxidant protein, improves endothelium-dependent relaxation in obese mice. However, whether UCP2 can be regulated by shear flow is unknown, and the role of endothelial UCP2 in regulating inflammation and atherosclerosis remains unclear.