Tropine - Wikipedia
Tropine is a central building block of many chemicals active in the nervous system, including tropane alkaloids. Some of these compounds, such as long-acting muscarinic antagonists are used as medicines because of these effects.
Atropine - Wikipedia
Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. [6] . It is typically given intravenously or by injection into a muscle. [6] .
Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and …
Tropane alkaloids (TAs) are a specific class of alkaloid and can be more specifically defined as all molecules that possess a tropane ring system (Figure 1 Structure of the tropane skeleton (green box) and the three major groups of TAs derived from, green box) [1].
Tropine - an overview | ScienceDirect Topics
Tropine is a muscarinic anticholinergic agent used to block nerve impulses, e.g., involuntary movements in the central and peripheral parasympathetic nervous system. From: Neuropathology of Drug Addictions and Substance Misuse, 2016
Tropine | C8H15NO | CID 449293 - PubChem
Tropine is a derivative of tropane having a hydroxy group at the 3-position. It has a role as a mouse metabolite. It is a conjugate base of a tropinium.
Tropine - an overview | ScienceDirect Topics
Tropinone is the first branch-point intermediate with a tropane ring in the TPA pathway. Two related dehydrogenases, tropinone reductase I (TR-I) and tropinone reductase II (TR-II), stereospecifically reduce the 3-keto group of tropinone to produce tropine and γ …
Biosynthesis of medicinal tropane alkaloids in yeast - Nature
Sep 2, 2020 · Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for treating neuromuscular disorders and are classified as essential medicines by the World Health...
Beauty of the beast: anticholinergic tropane alkaloids in therapeutics
In 1864, Kraut and Lossen revealed the stereochemistry and cleavage products (tropic acid and tropine) of atropine and hyoscyamine . Cocaine is considered as a ‘wonder medicine’ in the texts as it has local anaesthetic action and has role in treating postnatal depression and …
Engineering a microbial biosynthesis platform for de novo …
Aug 12, 2019 · Tropane alkaloids (TAs) are a group of phytochemicals that are used to treat neurological disorders. Here, the authors engineer baker’s yeast to produce tropine, a key intermediate in the ...
Tropine - an overview | ScienceDirect Topics
Tropine or tropinone bears seven-member carbon atoms joined in cyclic structure in the formation of cycloheptatriene or tropilidene, which is proved by the dehydration of tropine in Hoffman exhaustive methylation.