Tropane alkaloids are a class of bicyclic [3.2.1] alkaloids and secondary metabolites that contain a tropane ring in their chemical structure. [1] Tropane alkaloids occur naturally in many members of the plant family Solanaceae.

Tropane alkaloids (TAs) are a specific class of alkaloid and can be more specifically defined as all molecules that possess a tropane ring system (Figure 1 Structure of the tropane skeleton (green box) and the three major groups of TAs derived from, green box) .

Tropane is a nitrogenous bicyclic organic compound. It is mainly known for the other alkaloids derived from it, which include atropine and cocaine, among others. Tropane alkaloids occur in plants of the families Erythroxylaceae (including coca) and Solanaceae (including mandrake, henbane, deadly nightshade, datura, potato, tomato). [2] [3]

Jun 1, 2021 · Tropane alkaloids are a large group of compounds found in some of the Solanaceae, but not in food crops. They have a two-ringed structure characterized by a pyrrolidine and a piperidine ring that share a nitrogen atom and two carbons atoms. The most important tropane alkaloids are (−)-hyoscyamine and (−)-scopolamine (also known as hyoscine).

Tropane alkaloids are anticholinergic in action. TAs competitively bind to muscarinic and/or nicotinic receptors and block ACh transmission. MR: Muscarinic receptor; NR: Nicotinic receptor; ACh: Acetylcholine; PLC: Phospholipase C; AC: Adenylyl cyclase; MAPK: Mitogen-activated protein kinase [Prepared using Biorender.com]

Tropane alkaloids (TAs) are natural components contained in certain plants such as henbane, thornapple and deadly nightshade. Tropane alkaloids-containing plants are found in numerous families, such as Solanaceae, Erythroxylaceae, Convolvulaceae, Brassicaceae, and …

The term tropane alkaloids derived from the 8-membered bicyclic ring system with a methylated bridge forming nitrogen that is called 8-methyl-8-azabicyclo[3.2.1]octane (IUPAC) or tropane (trivial name).

Jun 21, 2023 · Toxicity from plants containing tropane alkaloids manifests as classic anticholinergic poisoning. Symptoms usually occur 30-60 minutes after ingestion and may continue for 24-48 hours because...

Tropane alkaloids (TA) are valuable secondary plant metabolites which are mostly found in high concentrations in the Solanaceae and Erythroxylaceae families. The TAs, which are characterized by their unique bicyclic tropane ring system, can be divided into three major groups: hyoscyamine and scopolamine, cocaine and calystegines.

Tropane alkaloids (TAs) are natural toxins produced by different plants, mainly from the Solanaceae family. The interest in TAs analysis is due to the serious cases of poisoning that are produced due to the presence of TA-producing plants in a variety of foods.